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Observations on antigenic variation in a strain of Trypanosoma brucei growing in mice

Published online by Cambridge University Press:  15 May 2009

J. F Watkins
J. F Watkins
Affiliation:
Sir William Dunn School of Pathology, University of Oxford
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Variation in agglutinating and protective antigens was studied in a strain of Trypanosoma brucei growing in mice protected with anti-trypanosomal rabbit serum. It was concluded that the agglutinating and protective antigens were the same, and that variation in the antigenic structure of trypanosome populations exposed to antiserum was due to mutation and selection rather than to adaptation. The mutation rate per organism per division cycle required to account for the experimental findings on the mutational hypothesis was found to have a mean value of 10−5.17.

Type
Research Article
Information
Journal of Hygiene , Volume 62 , Issue 1 , March 1964 , pp. 69 - 80
Copyright
Copyright © Cambridge University Press 1964

References

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