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A note on the safety testing of vaccines

Published online by Cambridge University Press:  15 May 2009

P. Armitage
P. Armitage
Affiliation:
London School of Hygiene and Tropical Medicine
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Summary

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The use of the hypergeometric distribution in calculations of sample volumes for safety testing is criticized. Alternative interpretations of the concept of ‘infective ml. doses’ lead to slightly different solutions, the simplest of which, involving the exponential function, is recommended for general use.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 1 , March 1971 , pp. 95 - 97
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Anderson, E. C., Capstick, P. B., Mowat, G. N. & Leech, F. B. (1970). In vitro method for safety testing of foot-and-mouth disease vaccines. Journal of Hygiene 68, 159.CrossRefGoogle ScholarPubMed
Peto, S. & Maidment, B. J. (1969). Tables of the upper limit to the estimate of the density of contaminating particles in a medium. Journal of Hygiene 67, 533.CrossRefGoogle Scholar