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Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines*

Published online by Cambridge University Press:  15 May 2009

A. N. Slepushkin ,
G. C. Schild ,
A. S. Beare ,
Susan Chinn  and
D. A. J. Tyrrell
A. N. Slepushkin
Affiliation:
Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, Common Cold Unit, Salisbury, Wilts, and World Influenza Centre, National Institute for Medical Research, Mill Hill, London, N.W. 7
G. C. Schild
Affiliation:
Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, Common Cold Unit, Salisbury, Wilts, and World Influenza Centre, National Institute for Medical Research, Mill Hill, London, N.W. 7
A. S. Beare
Affiliation:
Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, Common Cold Unit, Salisbury, Wilts, and World Influenza Centre, National Institute for Medical Research, Mill Hill, London, N.W. 7
Susan Chinn
Affiliation:
Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, Common Cold Unit, Salisbury, Wilts, and World Influenza Centre, National Institute for Medical Research, Mill Hill, London, N.W. 7
D. A. J. Tyrrell
Affiliation:
Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, Common Cold Unit, Salisbury, Wilts, and World Influenza Centre, National Institute for Medical Research, Mill Hill, London, N.W. 7
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Summary

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Thirty-seven volunteers were inoculated intranasally with living attenuated influenza A 2 viruses. Rising titres of circulating antineuraminidase (AN) were detected in 14 of 17 infected volunteers. AN was also found in nasal secretions. Statistical analysis showed that there was a correlation between the titres of haemagglutination-inhibituig antibody (HI) and AN in nasal washings, and between AN in blood and washings. Resistance to infection could be predicted from antibody titres in 29 of 37 volunteers and blood AN alone predicted the outcome of 25 volunteers.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 4 , December 1971 , pp. 571 - 578
Copyright
Copyright © Cambridge University Press 1971

References

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