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Nephropathia epidemica in Norway: antigen and antibodies in rodent reservoirs and antibodies in selected human populations

Published online by Cambridge University Press:  19 October 2009

T. Traavik ,
Ann-Inger Sommer ,
R. Mehl ,
B. P. Berdal ,
K. Stavem ,
O. H. Hunderi  and
J. M. Dalrymple
T. Traavik
Affiliation:
Institute of Medical Biology, University of Tromso and the Virological Laboratory, Regional Hospital of Tromso, Norway
Ann-Inger Sommer
Affiliation:
Institute of Medical Biology, University of Tromso and the Virological Laboratory, Regional Hospital of Tromso, Norway
R. Mehl
Affiliation:
Laboratory for Medical Entomology, National Institute of Public Health, Oslo, Norway
B. P. Berdal
Affiliation:
Norwegian Defence Microbiological Laboratory, Oslo, Norway
K. Stavem
Affiliation:
Vefsn Hospital, Mosjoen, Norway
O. H. Hunderi
Affiliation:
Ulleval Hospital, Oslo, Norway
J. M. Dalrymple
Affiliation:
U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, U.S.A.
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Nephropathia epidemica (NE) antigen was detected by IFAT (indirect fluorescent antibody technique) in the lungs of 14 of 97 bank voles (Clethrionomys glareolus) collected in three endemic areas. The distribution of antigen positive voles within an endemic location was scattered. Antibodies to Korean hemorrhagic fever (KHF) virus antigens were detected by IFAT in 12 of 14 NE antigen positive bank voles and in 15 of 83 that were antigen negative. NE antigen positive voles exhibited higher antibody titres. Antibodies to KHF were demonstrated in sera from C. rutilus and C. rufocanus collected more than 200 km north of the distribution area for C. glareolus. It appears likely that these vole species can serve as virus vectors for NE cases occurring north of the bank vole area. NE antibodies cross-reacting with KHF virus seem to diminish with time after infection in some NE patients, while for others such cross-reacting antibodies were detected up to 12 years after the disease. Antibodies to KHF were detected in eight of 106 healthy forestry workers with no clinical history of NE. No serological cross-reactions were detected between NE/KHF antigens and representative Bunyaviridae present in Norway. NE/KHF-like viruses appear widespread in Norway, both within and outside of the distribution area of the bank vole.

Type
Research Article
Information
Journal of Hygiene , Volume 93 , Issue 1 , August 1984 , pp. 139 - 146
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Brummkr-Korvenkontio, M., Vaheri, A., Von Bonsdorff, C. H., Vuouimies, J., Manni, T., Oker-Blom, N. & Lahdevirta, J. (1980). Nephropathia epidemica: detection of antigen in hank voles and serologie diagnosis of human infection. Journal of Infectious Diseases 141, 131–134.CrossRefGoogle Scholar
Donets, M. A., Rezapkin, G. V., Kouolev, M. B. & Tkachenko, E. A. (1982). Taxonomic features of causative agent of hemorrhngic fever with renal syndrome. Lancet i, 794–795.CrossRefGoogle Scholar
French, G. R., Foulke, R. S., Brand, O. A., Eddy, G. A., Lee, H. W. & Lee, P. W. (1981). Propagation of etiologic agent of Korean hemorrhagic fever in a cultured continuous cell line of human origin. Science 211, 1046–1048.CrossRefGoogle Scholar
Gavrilovskaya, T. N., Apekina, N. S., Garbachkova, E. A., Myasnikov, Yu Yu. A., Ryleva, E. V. & Chumakov, M. P. (1980). Detection by enzyme-linked immunosorbent assay of hemorrhagic fever with renal syndrome virus in lung suspensions of rodents from European USSR. Lancet ii, 1050.Google Scholar
Knutrud, O. (1949). Nehropathia epidemica. TidsskriftfordenNorske lAiegeforening 69, 259–261 (in Norwegian).Google Scholar
Lahdevirta, J. (1971). Nephropathia epidemica in Finland. A clinical, histological and epidemiological study. Annals of Clinical Research 3, suppl. 8.Google ScholarPubMed
Lee, H. W., Lee, P. W. & Johnson, K. M. (1978). Isolation of the etiologic agent of Korean hemorrhagic fever. Journal of Infectious Diseases 137, 298–308.CrossRefGoogle ScholarPubMed
Lee, H. W.Lee, P. W., Lahdevirta, J. & Brummer-Korvenkontio, M. (1979). Aetiological relation between Korean hemorrhagic fever and nephropathia epidemica. Lancet i, 186–187.Google Scholar
McCormick, J. B., Sasso, R., Palmer, E. L. & Kiley, M. P. (1982). Morphological identification of the agent of Korean hemorrhagic fever as a member of the Bunyaviridae. Lancet i, 765–768.CrossRefGoogle Scholar
Myhrman, G. (1934). En njursjukdom med egenartad symptombild. Nordisk Medisinsk Tidsskrift 7, 793–794.Google Scholar
Oker-Blom, N., Von Bonsdorff, C. H., Brummer-Korvenkontio, M., Hovi, T., Penttinen, K., Saikku, P., Vaheri, A. & Lahdevirta, J. (1979). Nephropathia epidemica in Finland. In Arctic and Tropical Arboviruses (ed. Kurstak, ), pp. 197–209. New York: Academic Press.CrossRefGoogle Scholar
Svedmyr, A. H., Lee, H. W.Berolund, A., Hoorn, B., Nystrom, K. & Gajdusek, D. C. (1979). Epidemic nephropathy in Scandinavia is related to Korean hemorrhagic fever. Lancet i, 100.CrossRefGoogle Scholar
Traavik, T. (1979). Tick and mosquito-associated viruses in Norway. Thesis, University of Tromso.Google Scholar
Traavik, T., Mehl, R., Bardal, B. P., Lund, S. & Dalrymple, J. M. (1983). Nephropathia epidemica in Norway: description of serological response in human disease and implication of rodent reservoirs. Scandinavian Journal of Infectious Diseases 15, 11–16.CrossRefGoogle ScholarPubMed
Traavik, T., Mehl, R. & Kjeldsberg, E. (1977). ‘Runde’ virus, a coronavirus-like agent associated with seabirds and ticks. Archives of Virology 55, 25–38.CrossRefGoogle Scholar
Traavik, T., Mehl, R. & Wider, R. (1984). Mosquito-borne arboviruses in Norway: further isolations and detection of antibodies to California encephalitis viruses in human, sheep and wildlife sera. Journal of Hygiene, submitted for publication.Google Scholar
Tsai, T. F., Dauer, S. P., Sasso, D. R., McCormick, J. B., Bradford, H., Caraway, C. T., McFarland, L. M., Medrano, O. & Saume, G. (1982). Preliminary evidence that Hantaan or a closely related virus is enzootic in domestic rodents. New England Journal of Medicine 307, 623.Google Scholar
White, J. D., Shirey, F. G., French, G. P., Huggins, J. W., Brand, O. M. & Lee, H. W. (1982). Hantaan virus, aetiological agent of Korean hemorrhagic fever has Bunyaviridae-like morphology. Lancet i, 768–771.CrossRefGoogle Scholar
Zetterholm, S. (1934). Akuta nefriter simulerande akuta bukfall. Lakartidningen 31, 425–429 (In Swedish).Google Scholar