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The nature of somatic phase variation and its importance in the serological standardization of O-suspensions of Salmonellas for use in the Widal Reaction

Published online by Cambridge University Press:  15 May 2009

William Hayes
William Hayes
Affiliation:
Central Military Pathological Laboratory, India Command
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1.Phase variation of the somatic antigen I in Bact. paratyphosum A and of the component XII2 in Bact. typhosum and British strains of Bact. enteritidis has been confirmed.

2. Strains of Bact. enteritidis isolated in India by blood culture from cases of invasive disease in man fall into two serological types, neither of which undergoes demonstrable somatic phase variation.

3. The probable mechanism of this type of variation is discussed in the light of experimental findings.

4. The effect which phase variation may have on the clarity of end-points in agglutinin titrations and on the serological standardization of Salmonella O-suspensions is demonstrated.

5. The variation is briefly discussed from the points of view of Salmonella philogeny and of human Salmonella infection.

I am indebted to the D.M.S. in India for permission to publish this paper.

Type
Research Article
Information
Journal of Hygiene , Volume 45 , Issue 2 , May 1947 , pp. 111 - 117
Copyright
Copyright © Cambridge University Press 1947

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