Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-25T06:21:13.461Z Has data issue: false hasContentIssue false
  • English
  • Français

Natural infection with influenza A (H3N2). The development, persistence and effect of antibodies to the surface antigens

Published online by Cambridge University Press:  15 May 2009

A. J. Smith  and
Joan R. Davies
A. J. Smith
Affiliation:
Public Health Laboratory, St Luke's Hospital, Guildford, GU1 3NT, Surrey
Joan R. Davies
Affiliation:
Public Health Laboratory, St Luke's Hospital, Guildford, GU1 3NT, Surrey
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A technique for estimating antibodies to the neuraminidase antigens of influenza A is described.

The antibody response to the haemagglutinin and neuraminidase antigens of influenza A (H3N2) was studied in a boys' public school over the four-year period 1970–4. During this time there were two outbreaks of influenza A and the effect of antibody on the result of natural challenge was investigated. No boy who had homotypic neuraminidase antibody had clinical influenza.

Type
Research Article
Information
Journal of Hygiene , Volume 77 , Issue 2 , October 1976 , pp. 271 - 282
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Aymard-Henry, M., Coleman, M. T., Dowdle, W. R., Laver, W. G., Schild, G. C. & Webster, R. G. (1973). Influenza neuraminidase and neuraminidase-inhibition test procedures. Bulletin of the World Health Organization 48, 199.Google ScholarPubMed
Couch, R. B., Kasel, J. A., Gerin, J. L., Schulman, J. L. & Kilbourne, E. D. (1974). Induction of partial immunity to influenza by a neuraminidase specific vaccine. Journal of Infectious Disease 129, 411.CrossRefGoogle ScholarPubMed
Dowdle, W. R., Galphin, J. C. & Noble, G. R. (1975). Interaction of neuraminidase antigens, antibodies and non-specific inhibitors. Symposium in influenza vaccination, Royal Society of Medicine 1975. Post Graduate Medical Journal (In the Press).Google Scholar
Dowdle, W. R., Sarateanu, D. & Reimer, C. B. (1972). Antiantibody enhancement of haemagglutination inhibition by influenza anti-neuraminidase. Journal of Immunology 109, 1321.CrossRefGoogle ScholarPubMed
Ham, R. G. & Puck, T. T. (1962). In Methods in Enzymology, Vol. 5(Ed. Colowick, S. P. and Kaplan, N. O.), p. 114. New York: Academic Press.Google Scholar
Hoskins, T. W., Davies, J. R., Allchin, A., Miller, C. L. & Pollock, T. M. (1973). Controlled trial of inactivated influenza vaccine containing the A Hong Kong strain during an outbreak of influenza due to the A/England/42/72 strain. Lancet ii, 116.CrossRefGoogle Scholar
Hoskins, T. W., Davies, J. R., Smith, A. J., Allchin, A., Miller, C. L. & Pollock, T. M. (1976). Influenza at Christ's Hospital, March 1974. Lancet i, 105.CrossRefGoogle Scholar
Murphy, B. R., Kasel, J. A. & Chanock, R. M. (1972). Association of serum antineur-aminidase antibody with resistance to influenza in man. New England Journal of Medicine 286, 1329.CrossRefGoogle ScholarPubMed
Rott, R., Becht, H. & Orlich, Michaela. (1974). The significance of influenza virus neur-aminidase in immunity. Journal of General Virology 22, 35.CrossRefGoogle ScholarPubMed
Schild, G. C., Henry-Aymard, M. & Pereira, H. G. (1972). A quantitative single radial diffusion test for immunological studies with influenza virus. Journal of General Virology 16, 231.CrossRefGoogle ScholarPubMed
Schild, G. C., Oxford, J. S. & Virelizier, J. L. (1975). Immunity to Influenza. International Symposium on Immunity to Infections of the Respiratory System in Man and Animals, in Developments in Biological Standardisation, Vol. 28(Ed. Perkins, F. T., Regamey, R. H. and Hennessen, W.), p. 253. Basel: Karger.Google Scholar
Slepushkin, A. N., Schild, G. C., Beare, A. S., Chinn, Susan & Tyrell, D. A. J. (1971). Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines. Journal of Hygiene 69, 571.Google ScholarPubMed