Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-25T19:30:57.694Z Has data issue: false hasContentIssue false
  • English
  • Français

Mycoplasma californicum mastitis in ewes as an experimental model for antibiotic treatment

Published online by Cambridge University Press:  19 October 2009

H. J. Ball ,
E. F. Logan  and
J. N. Campbell
H. J. Ball
Affiliation:
Veterinary Research Laboratories, Stoney Road, Stormont, Belfast BT4 3SD
E. F. Logan
Affiliation:
Veterinary Research Laboratories, Stoney Road, Stormont, Belfast BT4 3SD
J. N. Campbell
Affiliation:
Veterinary Research Laboratories, Stoney Road, Stormont, Belfast BT4 3SD
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A strain of Mycoplasma californicum successfully infected an experimentally inoculated ovine mammary gland causing a severe mastitis. The condition lasted for about 25 days, and resulted in atrophy and loss of milk production in the gland. Four experimentally infected ewes, treated over a 3-day period with various regimes of the antibiotics oxytetracycline or tylosin during the acute stage of infection, successfully eliminated the infection. Two others similarly treated with combined intramammary and intramuscular tiamulin or with intramammary Bay Vp2674, did not eliminate the infection; but another ewe treated with intramuscular as well as intramammary Bay Vp2674, did resolve the infection. The two ewes that were unsuccessfully treated with antibiotics at the acute stage did respond to tylosin or oxytetracycline at a later stage of infection. Measurement of antibiotic concentrations demonstrated that the persistence of inhibitory levels in the milk varied between the antibiotics and were influenced by the extent of parenteral treatment.

Type
Research Article
Information
Epidemiology & Infection , Volume 98 , Issue 3 , June 1987 , pp. 369 - 378
Copyright
Copyright © Cambridge University Press 1987

References

REFERENCES

Ball, H. J. & Mackie, D. P. (1984/1985). The experimental production of mastitis in ewes as a determinant of the virulence of ovine ureaplasma strains. Veterinary Microbiology 10, 117–123.CrossRefGoogle Scholar
Ball, H. J. & Mackie, D. P. (1985). The ovine mammary gland as an experimental model to determine the virulence of animal ureaplasmas. Journal of Hygiene 85, 375–382.CrossRefGoogle Scholar
Ball, H. J. & Mackie, D. P. (1986). Experimental production of bovine and ovine mastitis with a Mycoplasma canadense isolate. Veterinary Record 118, 72–73.CrossRefGoogle ScholarPubMed
Ball, H. J. & McCaughey, W. J. (1986). Investigation into the inhibitory effect of flurofamide on animal ureaplasmas and its use in the treatment of ureaplasma-infected sheep. Journal of Veterinary Pharmacology and Therapeutics 9, 280–285.CrossRefGoogle ScholarPubMed
Bennett, J., Brodie, J. L., Benner, E. J. & Kirby, W. M. M. (1966). Simplified, accurate method for antibiotic assay of clinical specimens. Applied Microbiology 14, 170–177.CrossRefGoogle ScholarPubMed
Boughton, E. (1979). Mycoplasma bovis mastitis. The Veterinary Bulletin 49, 377–387.Google Scholar
Jasper, D. E. (1977). Mycoplasma and mycoplasma mastitis. Journal of the American Veterinary Medical Association 170, 1167–1172.Google ScholarPubMed
Jasper, D. E. (1981). Bovine mycoplasmal mastitis. Advances in Veterinary Science and Comparative Medicine 25, 122–159.Google ScholarPubMed
Jasper, D. E., Erno, H., Dellinger, J. D. & Christiansen, C. (1981). Mycoplasma californicum, a new species from cows. International Journal of Systematic Bacteriology 31, 339–345.CrossRefGoogle Scholar
Jurmanová, K., Hájková, M. & Vévoda, J. (1983). Further evidence of the involvement of Mycoplasma californicum in bovine mastitis in Europe. Veterinary Record 112, 608.CrossRefGoogle ScholarPubMed
Jurmanová, K., Hájková, M., ˘erná, J., Borsuková, O. & Vévoda, J. (1985). The occurrence of mycoplasmic mastitis in Czechoslovakia. Veterinarni Medicina 30, 149–156.Google ScholarPubMed
Mackie, D. P., Ball, H. J. & Logan, E. F. (1982). Isolation of Mycoplasma californicuvi from an outbreak of bovine mastitis and the experimental reproduction of the disease. Veterinary Record 110, 578–580.CrossRefGoogle ScholarPubMed
Mackie, D. P., Ball, H. J. & Logan, E. F. (1986). Mycoplasma californicum mastitis in the dry dairy cow. Veterinary Record 119, 350–351.CrossRefGoogle Scholar
Taylor-Robinson, D., Purcell, R. H., Wong, D. C. & Chanock, R. M. (1966). A colour test for the measurement of antibody to certain mycoplasma species based upon the inhibition of acid production. Journal of Hygiene 64, 91–104.CrossRefGoogle ScholarPubMed
Subcommittee on the Taxonomy of Mycoplasmatales (1972). Proposal for minimal standards for descriptions of new species of the order Mycoplasmatales. International Journal of Systematic Bacteriology 22, 184–188.CrossRefGoogle Scholar