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Multiresistant Salmonella Typhimurium DT104 infections of humans and domestic animals in the Pacific Northwest of the United States

Published online by Cambridge University Press:  01 April 2000

T. E. BESSER ,
M. GOLDOFT ,
L. C. PRITCHETT ,
R. KHAKHRIA ,
D. D. HANCOCK ,
D. H. RICE ,
J. M. GAY ,
W. JOHNSON  and
C. C. GAY
T. E. BESSER
Affiliation:
Department of Veterinary Microbiology and Pathology, P.O. Box 647040, Washington State University, Pullman WA 99164-7040, USA
M. GOLDOFT
Affiliation:
Communicable Disease Epidemiology Section, Washington State Department of Health, 1610 NE 150th St, Shoreline WA 98155, USA
L. C. PRITCHETT
Affiliation:
Field Disease Investigation Unit, Washington State University, Pullman WA 99164-7060, USA
R. KHAKHRIA
Affiliation:
National Laboratory for Enteric Pathogens, Health Canada, HPB/IPS Bldg #7 AL, Tunney's Pasture, Ottawa Ontario Canada K1A 0L2
D. D. HANCOCK
Affiliation:
Field Disease Investigation Unit, Washington State University, Pullman WA 99164-7060, USA
D. H. RICE
Affiliation:
Field Disease Investigation Unit, Washington State University, Pullman WA 99164-7060, USA
J. M. GAY
Affiliation:
Field Disease Investigation Unit, Washington State University, Pullman WA 99164-7060, USA
W. JOHNSON
Affiliation:
National Laboratory for Enteric Pathogens, Health Canada, HPB/IPS Bldg #7 AL, Tunney's Pasture, Ottawa Ontario Canada K1A 0L2
C. C. GAY
Affiliation:
Field Disease Investigation Unit, Washington State University, Pullman WA 99164-7060, USA
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Abstract

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Salmonella Typhimurium definitive type 104 with chromosomally encoded resistance to five or more antimicrobial drugs (R-type ACSSuT+) has been reported increasingly frequently as the cause of human and animal salmonellosis since 1990. Among animal isolates from the northwestern United States (NWUS), R-type ACSSuT+ Typhimurium isolates increased through the early 1990s to comprise 73% of Typhimurium isolates by 1995, but subsequently decreased to comprise only 30% of isolates during 1998. NWUS S. Typhimurium R-type ACSSuT+ were consistently (99%) phage typed as DT104 or the closely related DTu302. S. Typhimurium isolates from cattle with primary salmonellosis, randomly selected from a national repository, from NWUS were more likely to exhibit R-type ACSSuT+ (19/24, 79%) compared to isolates from other quadrants (17/71, 24%; P < 0.01). Human patients infected with R-type ACSSuT+ resided in postal zip code polygons of above average cattle farm density (P < 0.05), while patients infected with other R-types showed no similar tendency. Furthermore, humans infected with R-type ACSSuT+ Typhimurium were more likely to report direct contact with livestock (P < 0.01) than humans infected with other R-types.

Type
Research Article
Information
Epidemiology & Infection , Volume 124 , Issue 2 , April 2000 , pp. 193 - 200
Copyright
© 2000 Cambridge University Press