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Mouse or man? Which are pertussis vaccines to protect?

Published online by Cambridge University Press:  15 May 2009

N. W. Preston  and
T. N. Stanbridge
N. W. Preston
Affiliation:
Department of Bacteriology and Virology, University of Manchester, Manchester M13 9PT
T. N. Stanbridge
Affiliation:
Department of Bacteriology and Virology, University of Manchester, Manchester M13 9PT
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Summary

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Type 1 strains of Bordetella pertussis can infect mouse brain and have been recovered as type 1 organisms after death. When introduced into the naso-pharynx of the marmoset, they immediately acquired agglutinogen 2 or 3, and the resulting type 1,2 or 1,3 infection persisted for many weeks.

As in the child, agglutinogens 2 and/or 3 appear to be essential for infection of the marmoset, whereas they are quite unnecessary in mouse brain. A vaccine (extract or whole cell) containing agglutinogen 1 may be sufficient to pass the mouse protection test but it may fail to immunize children. The mouse test is inadequate even for the screening of such extracts.

Type
Research Article
Information
Journal of Hygiene , Volume 76 , Issue 2 , April 1976 , pp. 249 - 256
Copyright
Copyright © Cambridge University Press 1976

References

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