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Molecular epidemiology of respiratory syncytial virus in The Gambia

Published online by Cambridge University Press:  01 February 1999

P. A. CANE ,
M. WEBER ,
M. SANNEH ,
R. DACKOUR ,
C. R. PRINGLE  and
H. WHITTLE
P. A. CANE
Affiliation:
Division of Immunity and Infection, University of Birmingham Medical School, Birmingham B15 2TT, UK Present address: CHD/WHO, CH–1211 Geneva 27, Switzerland.
M. WEBER
Affiliation:
Medical Research Council Laboratories, Fajara, PO Box 273, Banjul, The Gambia
M. SANNEH
Affiliation:
Medical Research Council Laboratories, Fajara, PO Box 273, Banjul, The Gambia
R. DACKOUR
Affiliation:
Medical Research Council Laboratories, Fajara, PO Box 273, Banjul, The Gambia
C. R. PRINGLE
Affiliation:
Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
H. WHITTLE
Affiliation:
Medical Research Council Laboratories, Fajara, PO Box 273, Banjul, The Gambia
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Abstract

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Respiratory syncytial virus (RSV) infection in The Gambia occurs seasonally in association with the rainy season. This study examined the genetic variability of RSV isolates from four consecutive epidemics from 1993–6. Each epidemic was made up of a number of variants which were replaced in subsequent epidemics. Analysis of attachment (G) protein gene sequences showed that isolates were closely related to those observed in the rest of the world. However, many isolates from 1993 and 1994 were unlike other isolates observed in the developed world during this period and were more similar to isolates from 1984 in Europe. In addition, the most commonly observed genotype in the UK in the 1990s was not detected in The Gambia during this period.

Type
Research Article
Information
Epidemiology & Infection , Volume 122 , Issue 1 , February 1999 , pp. 155 - 160
Copyright
© 1999 Cambridge University Press