Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-31T13:09:01.108Z Has data issue: false hasContentIssue false
  • English
  • Français

Molecular epidemiology of long-term colonization of Candida albicans strains from HIV-infected patients

Published online by Cambridge University Press:  19 August 2005

S. Y. LI ,
Y. L. YANG ,
K. W. CHEN ,
H. H. CHENG ,
C. S. CHIOU ,
T. H. WANG ,
T. L. LAUDERDALE ,
C. C. HUNG  and
H. J. LO
S. Y. LI
Affiliation:
Division of Laboratory Research and Development, Center for Disease Control, Taipei, Taiwan, ROC
Y. L. YANG
Affiliation:
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, ROC
K. W. CHEN
Affiliation:
Division of Laboratory Research and Development, Center for Disease Control, Taipei, Taiwan, ROC
H. H. CHENG
Affiliation:
Division of Clinical Research, National Health Research Institutes, Miaoli, Taiwan, ROC
C. S. CHIOU
Affiliation:
Division of Laboratory Research and Development, Center for Disease Control, Taipei, Taiwan, ROC
T. H. WANG
Affiliation:
Division of Laboratory Research and Development, Center for Disease Control, Taipei, Taiwan, ROC
T. L. LAUDERDALE
Affiliation:
Division of Clinical Research, National Health Research Institutes, Miaoli, Taiwan, ROC
C. C. HUNG
Affiliation:
Section of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital and Department of Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC
H. J. LO
Affiliation:
Division of Clinical Research, National Health Research Institutes, Miaoli, Taiwan, ROC
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Twenty-one Candida albicans isolates from three HIV-infected patients were collected over a period of 3 years and characterized for fluconazole susceptibility, infectivity and genetic relatedness. Fluconazole resistance was found in five isolates, four exhibited dose-dependent susceptibility and the remainder were fully susceptible to this agent. Pulsed-field gel electrophoresis of SfiI restriction digests of the genomic DNA from the isolates revealed that isolates from the same swab specimen were identical despite differences in susceptibility to fluconazole and isolates recovered over time from the three patients retained clonally related DNA fingerprints within each patient. This small-scale study confirms the persistence of oral colonization of C. albicans strains in HIV-infected patients. Clinical data also suggests that the primary infecting strain may become a persistent colonist in the oral cavity once the immune function of the patient has been restored.

Type
Short Report
Information
Epidemiology & Infection , Volume 134 , Issue 2 , April 2006 , pp. 265 - 269
Copyright
2005 Cambridge University Press