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Molecular epidemiology of human rotavirus

Published online by Cambridge University Press:  19 October 2009

P. Cash ,
E. Freebain ,
T. Brown  and
T. M. S. Reid
P. Cash
Affiliation:
From Department of Bacteriology, University of Aberdeen, Foresterhill, Aberdeen
E. Freebain
Affiliation:
From Department of Bacteriology, University of Aberdeen, Foresterhill, Aberdeen
T. Brown
Affiliation:
From Department of Bacteriology, University of Aberdeen, Foresterhill, Aberdeen
T. M. S. Reid
Affiliation:
Regional Laboratory, The City Hospital, Aberdeen
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The epidemiology of human rotavirus (HRV) in north-east Scotland was investigated between 1982 and 1984. During this period 708 HRV infections were recorded. The majority (83%) of the infections were in children less than 5 years of age although some were recorded in adults. The peak incidence occurred in the winter months although a high number of HRV infections was reported during the summer of 1983. A total of 840 faecal specimens containing rotavirus were screened for HRV genome RNA by polyacrylamide gel electrophoresis. Seven hundred (83%) specimens gave RNA profiles suitable for establishing the HRV electrophoretype. Twenty-five different electrophoretypes were identified, of which 21 had ‘long’ RNA profiles and four had ‘short’ RNA profiles. There was extensive co-circulation of distinct electrophoretypes although during any one epidemic period the majority of viruses belonged to a relatively small number of types. Comparison of viruses collected from hospitalized and non-hospitalized Patients showed no differences in electrophoretype distribution. HRV was identified in faecal specimens from a wide age group and no correlation was demonstrated between age of patient and electrophoretype of the infecting virus.

Type
Research Article
Information
Journal of Hygiene , Volume 96 , Issue 2 , April 1986 , pp. 265 - 275
Copyright
Copyright © Cambridge University Press 1986

References

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