Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-22T15:37:31.486Z Has data issue: false hasContentIssue false
  • English
  • Français

A method for measuring the retained dose in experiments on airborne infection

Published online by Cambridge University Press:  15 May 2009

G. J. Harper  and
J. D. Morton
G. J. Harper
Affiliation:
Microbiological Research Establishment, Porton, Salisbury, Wilts.
J. D. Morton
Affiliation:
Microbiological Research Establishment, Porton, Salisbury, Wilts.
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

When killed radioactive bacterial spores are inhaled by guinea-pigs and retained in the lung, it is found that the rate of loss up to 5 weeks later is sufficiently constant for the initial retention of a group of animals to be calculated from the measured retention at a later time (say 3 weeks after exposure). If, therefore, the inhaled cloud contained also a pathogen, in known proportion to the spores, the initial retention of the pathogen could be calculated. The experiments apply to groups of animals, but it is believed that the conclusions are valid also for single animals. In experiments with Br. suis it was found that the fate, as regards infection, of individual animals within a group exposed to a common dosage was not significantly related to the estimated retained dose, despite the wide variation of individual doses about the group mean.

Type
Research Article
Information
Journal of Hygiene , Volume 60 , Issue 2 , June 1962 , pp. 249 - 257
Copyright
Copyright © Cambridge University Press 1962

References

REFERENCES

Ames, A. M. & Nungester, W. J. (1949). J. infect. Dis. 84, 56.CrossRefGoogle Scholar
Druett, H. A. (1952). Nature, Lond., 170, 288.CrossRefGoogle Scholar
Guyton, A. C. (1947). Amer. J. Physiol. 150, 70.CrossRefGoogle Scholar
Harper, G. J. & Morton, J. D. (1952). J. gen. Microbiol. 7, 98.CrossRefGoogle Scholar
Harper, G. J. & Morton, J. D. (1953). J. Hyg., Camb., 51, 372.CrossRefGoogle Scholar
Harper, G. J. (1955). Brit. J. exp. Path. 36, 60.Google Scholar
Henderson, D. W. (1952). J. Hyg., Camb., 50, 53.CrossRefGoogle Scholar
Henderson, D. W., Peacock, S. & Belton, F. C. (1956). J. Hyg., Camb., 54, 28.CrossRefGoogle Scholar
Mccullough, W. G., Mills, R. C., Herbst, E. J., Roessler, W. G. & Brewer, C. R. (1947). J. Bact. 53, 5.CrossRefGoogle Scholar
May, K. R. & Harper, C. J. (1957). Brit. J. industr. Med. 14, 287.Google Scholar
Peto, S. (1953). Biometrics 9, 320.CrossRefGoogle Scholar
Powell, E. O. (1957). J. appl. Bact. 20, 342.Google Scholar
Rosebury, T. (1947). Experimental Airborne Infection. Baltimore, U.S.A.Williams and Wilkins.Google Scholar