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A major gene controlling warfarin-resistance in the house mouse

Published online by Cambridge University Press:  15 May 2009

Margaret E. Wallace  and
Felicity J. MacSwiney
Margaret E. Wallace
Affiliation:
Department of Genetics, University of Cambridge
Felicity J. MacSwiney
Affiliation:
Department of Genetics, University of Cambridge
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Summary

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The spread of a 'cream' mutant in a wild population of house mice is reported. The hypothesis that the gene responsible for the colour, extreme chinchilla, ce, has spread because of linkage with a major gene for warfarin-resistance, is tested by a linkage backcross.

The results prove that a major gene does exist, that it is very closely linked with frizzy, fr, in chromosome 7, which in turn is linked with ce, that it is fully dominant in females at 4 months of age, and that its partial dominance in males is under the control of modifiers.

The symbol War is proposed for the gene. Its position in chromosome 7 is analagous with the position of the resistant gene, Rw2, in the rat in the analagous chromosome.

The adaptive significance of this finding is discussed, as also are reports of certain other mutants in wild populations of mice.

Type
Research Article
Information
Journal of Hygiene , Volume 76 , Issue 2 , April 1976 , pp. 173 - 181
Copyright
Copyright © Cambridge University Press 1976

References

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