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M genotyping and DNA fingerprinting of Streptococcus pyogenes isolates from an area of central Italy

Published online by Cambridge University Press:  01 August 1998

M. MENCARELLI ,
R. CORBISIERO ,
B. MARZOCCHI ,
A. GISTRI ,
R. SIGNORI ,
A. ROSSOLINI  and
C. CELLESI
M. MENCARELLI
Affiliation:
Institute of Clinical Infectious Disease, University of Siena, Siena, Italy
R. CORBISIERO
Affiliation:
Institute of Clinical Infectious Disease, University of Siena, Siena, Italy
B. MARZOCCHI
Affiliation:
Institute of Clinical Infectious Disease, University of Siena, Siena, Italy
A. GISTRI
Affiliation:
Institute of Clinical Infectious Disease, University of Siena, Siena, Italy
R. SIGNORI
Affiliation:
Institute of Clinical Infectious Disease, University of Siena, Siena, Italy
A. ROSSOLINI
Affiliation:
Institute of Clinical Infectious Disease, University of Siena, Siena, Italy
C. CELLESI
Affiliation:
Institute of Clinical Infectious Disease, University of Siena, Siena, Italy
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Abstract

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M protein gene typing was used to analyse Streptococcus pyogenes clinical isolates collected between 1983 and 1995 in an area of central Italy from patients presenting different types of infections; the same isolates were also characterized by means of DNA fingerprinting.

M type 1 was the most common (50% of study strains), followed by M types 4, 12 and 6. The proportion of M type 12 decreased with time, whereas M type 1 increased, in agreement with data obtained in many different areas. Most invasive strains belonged to types M1 (30%) and M12 (30%); on the other hand, the M1 type did frequently occur also among non-invasive isolates. DNA fingerprinting showed a correlation between M types and DNA patterns. This report provides epidemiological information from a geographic area not sampled recently, and further shows the usefulness of the M genotyping technique, which offers potential advantages over conventional serological typing methods.

Type
Research Article
Information
Epidemiology & Infection , Volume 121 , Issue 1 , August 1998 , pp. 77 - 84
Copyright
© 1998 Cambridge University Press