Long-term persistence of Coxiella burnetii in the host after primary Q fever

R. J. HARRIS; P. A. STORM; A. LLOYD; M. ARENS; B. P. MARMION

doi:10.1017/S0950268899003763

Abstract

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After a primary infection Coxiella burnetii may persist covertly in animals and recrudesce at parturition to be shed in the products of conception and the milk. Similar latent persistence and recrudescence occurs in man: namely, infection of placenta, heart valve or mural endocardium, bone or liver. The numbers of organisms, their viability and cellular form, and the underlying organ sites of latent infection for the coxiella are obscure. During investigations of 29 patients with a chronic sequel to acute Q fever, the post-Q fever fatigue syndrome (QFS) [1–3], sensitive conventional and TaqMan-based PCR revealed low levels of C. burnetii DNA in blood mononuclear cells (5/29; 17%), thin needle liver biopsies (2/14; 14%) and, notably, in bone marrow aspirates (13/20; 65%). Irrespective of the ultimate significance of coxiella persistence for QFS, the detection of C. burnetii genomic DNA in bone marrow several years after a primary infection unveils a new pathological dimension for Q fever.

Crossref Citations

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Milazzo, Adriana Hall, Robert Storm, Paul A. Harris, Ray J. Winslow, William and Marmion, Barrie P. 2001. Sexually Transmitted Q Fever. Clinical Infectious Diseases, Vol. 33, Issue. 3, p. 399.

Fenollar, Florence Fournier, Pierre‐Edouard Carrieri, M. Patrizia Habib, Gilbert Messana, Thierry and Raoult, Didier 2001. Risks Factors and Prevention of Q Fever Endocarditis. Clinical Infectious Diseases, Vol. 33, Issue. 3, p. 312.

Baquero-Artigao, Fernando Castillo, Fernando del and Tellez, Alicia 2002. ACUTE Q FEVER PERICARDITIS FOLLOWED BY CHRONIC HEPATITIS IN A TWO-YEAR-OLD GIRL. The Pediatric Infectious Disease Journal, Vol. 21, Issue. 7, p. 705.

McQuiston, Jennifer H. Childs, James E. and Thompson, Herbert A. 2002. Q fever. Journal of the American Veterinary Medical Association, Vol. 221, Issue. 6, p. 796.

Fournier, Pierre-Edouard and Raoult, Didier 2003. Comparison of PCR and Serology Assays for Early Diagnosis of Acute Q Fever. Journal of Clinical Microbiology, Vol. 41, Issue. 11, p. 5094.

Komiya, Tomoyoshi Toriniwa, Hiroko Sadamasu, Kenji Fukushi, Hideto Hirai, Katsuya Arashima, Yasutomo Kato, Kimitoshi and Arakawa, Yasuyuki 2003. Epidemiological survey on the route of Coxiella burnetii infection in an animal hospital. Journal of Infection and Chemotherapy, Vol. 9, Issue. 2, p. 151.

Langley, Joanne M. Marrie, Thomas J LeBlanc, John C. Almudevar, Anthony Resch, Lothar and Raoult, Didier 2003. Coxiella burnetii seropositivity in parturient women is associated with adverse pregnancy outcomes. American Journal of Obstetrics and Gynecology, Vol. 189, Issue. 1, p. 228.

Madariaga, Miguel G Rezai, Katayoun Trenholme, Gordon M and Weinstein, Robert A 2003. Q fever: a biological weapon in your backyard. The Lancet Infectious Diseases, Vol. 3, Issue. 11, p. 709.

Helbig, K J Heatley, S L Harris, R J Mullighan, C G Bardy, P G and Marmion, B P 2003. Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome. Genes & Immunity, Vol. 4, Issue. 1, p. 82.

Woldehiwet, Zerai 2004. Q fever (coxiellosis): epidemiology and pathogenesis. Research in Veterinary Science, Vol. 77, Issue. 2, p. 93.

Nourse, Clare Allworth, Anthony Jones, Andrew Horvath, Robert McCormack, Joe Bartlett, Jeremy Hayes, David and Robson, Jennifer M. 2004. Three Cases of Q Fever Osteomyelitis in Children and a Review of the Literature. Clinical Infectious Diseases, Vol. 39, Issue. 7, p. e61.

MILLER, J 2004. A growth study of Coxiella burnetii Nine Mile Phase I and Phase II in fibroblasts. FEMS Immunology and Medical Microbiology, Vol. 42, Issue. 3, p. 291.

Marrie, Thomas J 2004. Q fever pneumonia. Current Opinion in Infectious Diseases, Vol. 17, Issue. 2, p. 137.

Takahashi, Hiroshi Tokue, Yutaka Kikuchi, Toru Kobayashi, Takao Gomi, Kazuhiro Goto, Ikuo Shiraishi, Hiroyuki Fukushi, Hideto Hirai, Katuya Nukiwa, Toshihiro and Watanabe, Akira 2004. Prevalence of community-acquired respiratory tract infections associated with Q fever in Japan. Diagnostic Microbiology and Infectious Disease, Vol. 48, Issue. 4, p. 247.

ARASHIMA, Yasutomo KATO, Kimitoshi KOMIYA, Tomoyoshi KUMASAKA, Kazunari MATSUKAWA, Yoshihiro MURAKAMI, Masato TAKAHASHI, Katsuyuki IKEDA, Tadao and ARAKAWA, Yasuyuki 2004. Improvement of Chronic Nonspecific Symptoms by Long-term Minocycline Treatment in Japanese Patients with Coxiella burnetii Infection Considered to Have Post-Q Fever Fatigue Syndrome. Internal Medicine, Vol. 43, Issue. 1, p. 49.

Marmion, B.P. Storm, P.A. Ayres, J.G. Semendric, L. Mathews, L. Winslow, W. Turra, M. and Harris, R.J. 2005. Long-term persistence of Coxiella burnetii after acute primary Q fever. QJM, Vol. 98, Issue. 1, p. 7.

Shannon, Jeffrey G. Howe, Dale and Heinzen, Robert A. 2005. VirulentCoxiella burnetiidoes not activate human dendritic cells: Role of lipopolysaccharide as a shielding molecule. Proceedings of the National Academy of Sciences, Vol. 102, Issue. 24, p. 8722.

KAZAR, JAN 2005. Coxiella burnetiiInfection. Annals of the New York Academy of Sciences, Vol. 1063, Issue. 1, p. 105.

Camacho, MT Outschoorn, I Tellez, A and Sequí, J 2005. Autoantibody profiles in the sera of patients with Q fever: characterization of antigens by immunofluorescence, immunoblot and sequence analysis. Journal of Autoimmune Diseases, Vol. 2, Issue. 1,

2005. Coxiella burnetii – Pathogen of the Q (Query) Fever. Transfusion Medicine and Hemotherapy, Vol. 32, Issue. 3-4, p. 218.

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Long-term persistence of Coxiella burnetii in the host after primary Q fever

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