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Longitudinal study of rotavirus infections among children from Belém, Brazil

Published online by Cambridge University Press:  15 May 2009

A. C. Linhares ,
Y. B. Gabbay ,
R. B. Freitas ,
E. S. Travassos da Rosa ,
J. D. P. Mascarenhas  and
E. C. B. Loureiro
A. C. Linhares
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
Y. B. Gabbay
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
R. B. Freitas
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
E. S. Travassos da Rosa
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
J. D. P. Mascarenhas
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
E. C. B. Loureiro
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
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From December 1982 to March 1986 a group of 80 children between 0 and 3 years old who lived in the peripheral area of Belém, Brazil, were followed up for episodes of diarrhoea. A total of 441 diarrhoeal episodes were recorded and 36 (8·2%) were associated with rotavirus. This agent was the only pathogen in 50% of rotavirus-related episodes of acute diarrhoea, and strains were characterized by analysis of RNA in polyacrylamide gels. Forty-one belonged to subgroup II (long pattern) and five to subgroup I. Reinfections by rotavirus were noted in 12 children involving either the same or different subgroups. Ten distinct electrophoretypes were detected in the study period and the predominant one had the ‘1N2L’ profile. The cumulative age-specific attack rate for diarrhoea reached 2–8 by the end of the first year of life; a frequency of 2–3 episodes of diarrhoea per child per year was observed throughout the complete investigation. In comparing the age-specific attack rates for diarrhoea between breast-fed and bottle-fed children, a peak at 6 months of age was noted in the former, and at 1 month in the latter. A comparison by Fischer's exact test (P = 0·21) provided no evidence for protection against clinical rotavirus disease by maternal milk. By the same test, however (P = 0·021), we found significant evidence that early rotavirus infections were more likely to be asymptomatic and that infections after 4 months were more likely to be symptomatic. The clinical picture in children with rotavirus-related diarrhoea was more severe than in those suffering from acute diarrhoea due to another agent.

Type
Research Article
Information
Epidemiology & Infection , Volume 102 , Issue 1 , February 1989 , pp. 129 - 145
Copyright
Copyright © Cambridge University Press 1989

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