Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2025-01-05T12:51:54.911Z Has data issue: false hasContentIssue false
  • English
  • Français

Live influenza B vaccine in volunteers

A report to the Medical Research Council by their Committee on Influenza and Other Respiratory Virus Vaccines*

Published online by Cambridge University Press:  15 May 2009

A. S. Beare ,
D. A. J. Tyrrell ,
D. Hobson ,
C. H. L. Howells ,
M. S. Pereira ,
T. M. Pollock  and
L. E. Tyler
A. S. Beare
Affiliation:
Common Cold Research Unit, Salisbury
D. A. J. Tyrrell
Affiliation:
Common Cold Research Unit, Salisbury
D. Hobson
Affiliation:
Bacteriology Department, University of Liverpool
C. H. L. Howells
Affiliation:
Virus Laboratory, New Cross Hospital, Wolverhampton
M. S. Pereira
Affiliation:
Central Public Health Laboratory, Colindale, London, N.W.9
T. M. Pollock
Affiliation:
Central Public Health Laboratory, Colindale, London, N.W.9
L. E. Tyler
Affiliation:
General Practitioner, Wolverhampton
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A trial of an experimental live influenza B vaccine has been described.

The virus it contained was active and produced infections, antibody rises and clinical reactions.

Second and third vaccinations had much less effect than the first. Resistance to revaccination was only partially reflected in the serological response.

It seems that another factor, probably local antibody, exerts a considerable influence on resistance to infection with influenza viruses.

We are greatly indebted to Dr P. G. Higgins of the Public Health Laboratory, Cirencester, who went to much trouble to provide us with specimens from patients with influenza; to Dr H. G. Pereira of the National Institute for Medical Research for the antigenic analysis of the vaccine virus; to Messrs Sankey Ltd., Bilston, Wolverhampton, for their unfailing courtesy and forbearance throughout the trial; to the volunteers for their enthusiastic co-operation in the face of some discom forts; and to Messrs Pfizer Ltd., Sandwich, for originally providing facilities for the preparation of the vaccine.

In particular we wish to record our gratitude for the invaluable technical help of Miss Pamela Ball of the Common Cold Research Unit, Mrs Maria Gregory of the Bacteriology Department of Liverpool University, Mrs L. Johnson of the Virus Laboratory of New Cross Hospital, Wolverhampton, and Mr A. Westoby, an assistant in the practice of Dr Tyler.

Type
Research Article
Information
Journal of Hygiene , Volume 67 , Issue 1 , March 1969 , pp. 1 - 11
Copyright
Copyright © Cambridge University Press 1969

References

Andrews, B. E., Beare, A. S., McDonald, J. C., Zuckerman, A. J. & Tyrrell, D. A. J. (1966). Further trials of live influenza vaccine. Br. med. J. i, 637.Google Scholar
Beare, A. S. (1962). Neutralization and haemagglutination-inhibition tests in a live influenza vaccine trial. Mon. Bull. Minist. Hlth 21, 167.Google Scholar
Beare, A. S., Tyrrell, D. A. J., McDonald, J. C., Pollock, T. M., Taylor, C. E. D., Howells, C. H. L. & Tyler, L. E. (1967). Reactions and antibody response to live influenza vaccine prepared from the Iksha (A 2) strain. (A report to the Medical Research Council by their Committee on Influenza and Other Respiratory Virus Vaccines.) J. Hyg., Camb. 65, 245.Google Scholar
Communicable Disease Center (1965). Influenza Surveillance Report, no. 81, pp. 21–3..Google Scholar
Henle, W. & Lief, F. S. (1963). The broadening of antibody spectra following multiple exposures to influenza viruses. Am. Rev. resp. Dis. 88, no. 3, ii, 379.Google Scholar
Lief, F. S. & Henle, W. (1956). Studies on the soluble antigen of influenza virus. II. A comparison of the effects of sonic vibration and ether treatment of elementary bodies. Virology 2, 772.Google Scholar
McDonald, J. C., Zuckerman, A. J., Beare, A. S. & Tyrrell, D. A. J. (1962). Trials of live influenza vaccine in the Royal Air Force. Br. med. J. i, 1036.Google Scholar
Pereira, M. S., Chakraverty, P., Pollock, T. M. & Pope, J. G. (1967). Survey of influenza antibody in England by the strain-specific complement-fixation test. Br. med. J. iv, 80.CrossRefGoogle Scholar
Sever, J. L. (1962). Application of a microtechnique to viral serological investigations. J. Immun. 88, 320.CrossRefGoogle ScholarPubMed
Smith, C. B., Purcell, R. H., Bellanti, J. A. & Chanock, R. M. (1966). Protective effect of antibody to parainfluenza type 1 virus. New Engl. J. Med. 275, 1145.Google Scholar
Smorodintsev, A. A., Alexandrova, G. A., Chalkina, O. M. & Selivanov, A. A. (1965). Experience in the development of live vaccines against influenza and influenza-like respiratory infections. Appl. Virol.: 1st Annu. Symp., Boca Baton, Fla., 1964, p. 142.Google Scholar
World Health Organization (1953). Expert Committee on Influenza. Tech. Rep. Ser. Wld Hlth Org. no. 64.Google Scholar