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Litter-Mate Assays of Pertussis Vaccine

Published online by Cambridge University Press:  15 May 2009

J. O. Irwin  and
A. F. B. Standfast
J. O. Irwin
Affiliation:
The Medical Research Councils' Statistical Research Unit, London School of Hygiene and Tropical Medicine, and the Lister Institute of Preventive Medicine, Elstree, Herts
A. F. B. Standfast
Affiliation:
The Medical Research Councils' Statistical Research Unit, London School of Hygiene and Tropical Medicine, and the Lister Institute of Preventive Medicine, Elstree, Herts
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Summary

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A series of comparative assays of two pertussis vaccines was carried out by the mouse intracerebral method, using litter-mates and placing one member of each litter on each dose.

A statistical analysis of the results by the method described by Irwin (1950, p. 231), was carried out, making due allowance for the use of litter-mates. A slight increase of accuracy was found in five out of six assays, but this did not reach the 5% level of significance. Any real increase of accuracy must have been small. The results show that, as far as these tests are concerned, there is no advantage in the use of litter-mates, particularly when one takes account of the large amount of additional work necessary in the animal house.

Type
Research Article
Information
Journal of Hygiene , Volume 53 , Issue 1 , March 1955 , pp. 106 - 111
Copyright
Copyright © Cambridge University Press 1955

References

Irwin, J. O. (1950). Biological assays with special reference to biological standards. J. Hyg., Camb., 48, 215–38.CrossRefGoogle ScholarPubMed
Kendrick, P. L., Elderling, G., Dixon, M. K. & Misner, J. (1947). Mouse protection tests in the study of pertussis vaccine. Amer. J. publ. Hlth, 37, 803.CrossRefGoogle Scholar