Hostname: page-component-7479d7b7d-8zxtt Total loading time: 0 Render date: 2024-07-15T20:48:11.399Z Has data issue: false hasContentIssue false

Invasive nosocomial pulmonary aspergillosis: risk factors and hospital building works

Published online by Cambridge University Press:  19 October 2009

M. Perraud
Affiliation:
Hospital Hygiene Laboratory, Hôpital Edouard Herriot, 69003 Lyon, France
M. A. Piens
Affiliation:
Parasitology Laboratory, Domaine Universitaire, 8 avenue Rockefeller, 69373 Lyon, France
N. Nicoloyannis
Affiliation:
Hospital Hygiene Laboratory, Hôpital Edouard Herriot, 69003 Lyon, France
P. Girard
Affiliation:
Hospital Hygiene Laboratory, Hôpital Edouard Herriot, 69003 Lyon, France
M. Sepetjan
Affiliation:
Hospital Hygiene Laboratory, Hôpital Edouard Herriot, 69003 Lyon, France
J. P. Garin
Affiliation:
Parasitology Laboratory, Domaine Universitaire, 8 avenue Rockefeller, 69373 Lyon, France
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A retrospective epidemiological study of 22 observations of invasive pulmonary aspergillosis, of which 18 were fatal, occurring over a period of 30 months, implicated certain building sites within the hospital. The building works were responsible for the diffusion into the atmosphere of fungal spores from normally closed reservoirs, notably false ceilings, fibrous thermal and/or acoustic insulation materials and roller-blind casings. The results of our study permit us to suggest that protective measures should be set up or that immunodepressed patients are evacuated when such works are to be carried out in an in-patient establishment.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1987

References

REFERENCES

Aisner, J., Schimpf, S. C., Bennett, J. E., Young, V. M. & Wieunick, P. H. (1976). Aspergillus infections in cancer patients. Association with fire proofing materials in a new hospital. Journal of the American Medical Association 235, 411412.CrossRefGoogle Scholar
Arnow, P. M., Andersen, R. M., Mainous, P. D. & Smith, E. J. (1978). Pulmonary aspergillosis during hospital renovation. American Review of Respiratory Disease 118, 4053.Google Scholar
Burton, J. R., Zacheky, J. B., Bessin, R., Bathbun, H. K., Greenough, W. B., Sterioff, S., Wright, J. R., Slavin, R. E. & Williams, G. H. (1972). Aspergillosis in four renal transplant recipients. Diagnostic and effective treatment with amphotcricin B. Annals of Internal Medicine 77, 383388.CrossRefGoogle ScholarPubMed
Krick, J. A. & Remington, J. S. (1976). Opportunistic invasive fungal infections in patients with leukemia and lymphoma. Clinical Haematology 5, 249310.CrossRefGoogle Scholar
Leclerc, P., Capron, F., de Fenoyl, O., Bientz, M. & Rochemaure, J. (1982). Pneumopathies infectieuses de l'immunosuppression. Le Poumon el le Cœur 38, 101110.Google Scholar
Lentino, J. R., Rosenkarnz, M. A., Michaels, J. A., Kurup, V. P., Rose, H. D. & Rytel, N. W. (1982). Nosocomial aspergillosis. A retrospective review of airborne disease secondary to road construction and contaminated air conditioners. American Journal of Epidemiology 116, 430434.CrossRefGoogle ScholarPubMed
Mahoney, J. R., Steuber, C. P., Starling, K. A., Barrett, F. F., Golherg, J. & Fernbach, D. J. (1979). An outbreak of aspergillosis in children with acute leukemia. Journal of Pediatrics 95, 7072.CrossRefGoogle ScholarPubMed
Piens, M. A., Perraud, M. & Monier, M. F. (1983). Mise en évidence de spores d' Aspergillus fumigatus dans l'atmosphère d' un service d'Hématologio au cours d' une épidémic d' Aspergillose pulmonaire invasive. Bulletin de la Société Française de Mycologie Médicale 12, 265268.Google Scholar
Prytowski, S. D., Vogelstein, B., Ettinger, D. S., Merz, W. G., Kaizer, H., Sulica, V. I. & Zinkham, W. H. (1976). Invasive aspergillosis. New England Journal of Medicine 295, 655658.CrossRefGoogle Scholar
Rose, H. D. (1972). Mechanical control of hospital ventilation and Aspergillus infection. American Review of Respiratory Disease 105, 306307.Google Scholar
Sayer, W. J., Shean, D. B. & Ghosseliri, Y. (1969). Estimation of airborne fungal flora by the Andersen samples versus the gravity setting culture plate. Journal of Allergy 44, 214218.CrossRefGoogle Scholar
Sarubbi, F. A., Kopf, H. B., Wilson, M. B., McGinnis, H. R. & Rutala, W. A. (1982). Increased recovery of Aspergillus flavus from respiratory specimens during hospital construction. American Review of Respiratory Dinease 125, 3338.Google ScholarPubMed
Streifel, A. J., Lauer, J. L., Vesley, D., Juni, B. & Rhame, F. S. (1983). Aspergillus fumigatus and other thermotolerant fungi generated by hospital building demolition. Applied and Environmental Microbiology 46, 375378.CrossRefGoogle ScholarPubMed
Tricot, G., Joosten, E., Boogaerts, M. A., Vande Pitte, J. & Cauwenbergh, G. (1987). Ketoconazolo vs. itraconazolo for antifungal prophylaxis in patients with severe granulocytopenia: preliminary results of two nonrandomized studies. Reviews of Infectious Diseases 9 suppl. 1, 595599.Google Scholar