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Invasive group A streptococcal infections in the San Francisco Bay area, 1989–99

Published online by Cambridge University Press:  10 January 2003

D. J. PASSARO
Affiliation:
California Emerging Infections Program, Oakland, CA 94617, USA
D. S. SMITH
Affiliation:
California Emerging Infections Program, Oakland, CA 94617, USA Current affiliation: Kaiser Permanente-Redwood City Medical Center, Redwood City, CA 94063, USA.
E. C. HETT
Affiliation:
California Emerging Infections Program, Oakland, CA 94617, USA Current affiliation: Harvard School of Public Health, Boston, MA 02115, USA.
A. L. REINGOLD
Affiliation:
Division of Public Health Biology and Epidemiology, University of California at Berkeley, Berkeley, CA 94720, USA
P. DAILY
Affiliation:
California Emerging Infections Program, Oakland, CA 94617, USA
C. A. VAN BENEDEN
Affiliation:
Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
D. J. VUGIA
Affiliation:
Disease Investigations and Surveillance Branch, California Department of Health Services, Berkeley, CA 94704, USA
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Abstract

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To describe the epidemiology of invasive group A streptococcal (iGAS) infections in the San Francisco Bay Area, population-based active surveillance for laboratory-confirmed iGAS was conducted by the California Emerging Infections Program in three California counties. From January 1989 to December 1999, 1415 cases of iGAS were identified. Mean iGAS incidence was 4·06/100 000 person-years and case fatality ratio was 13%, with no linear trends over time. Incidence was lowest in adolescents, was higher in men than women (4·4 vs. 3·2/100 000 person-years), and was higher in African–Americans (6·7) than in non-Hispanic (4·1) or Hispanic (3·4) Whites, Asians (2·2) or Native Americans (1·7/100 000 person-years). Injecting drug use was the riskiest underlying condition and was associated with the highest attributable risk. Cases were associated with several underlying conditions, but 23% occurred in previously healthy persons. From 1989–1999, iGAS infections in the San Francisco Bay Area became neither more common nor more deadly.

Type
Research Article
Copyright
2002 Cambridge University Press