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The intracerebral infection of mice with Bordetella pertussis

Published online by Cambridge University Press:  15 May 2009

Jean M. Dolby  and
A. F. B. Standfast
Jean M. Dolby
Affiliation:
The Lister Institute of Preventive Medicine, Elstree, Hertfordshire
A. F. B. Standfast
Affiliation:
The Lister Institute of Preventive Medicine, Elstree, Hertfordshire
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The growth of virulent strains of Bordetella pertussis in the brains of mice was studied by carrying out viable counts on mice killed at various times during the infection. The results suggested that this system conformed to the general model which postulates that the organisms causing death multiply in vivo at a rate which is constant for all doses and that death is certain to occur when the number of organisms reaches a certain constant figure.

Perhaps the most important factor in this route of infection is the lodgement of the parasite in the host, for if this is accomplished a single organism grows until the lethal level is reached. There is no sublethal infection.

In actively and passively protected mice, the growth of the organism is approximately the same as in unprotected controls for the first 4–5 days. At this time there is a striking change in protected animals and the viable count falls rapidly and progressively and the animals survive. At the same time the blood-brain barrier becomes permeable and circulating antibodies diffuse into the brain. In vitro, specific antisera plus complement are highly bactericidal.

Type
Research Article
Information
Journal of Hygiene , Volume 59 , Issue 2 , June 1961 , pp. 205 - 216
Copyright
Copyright © Cambridge University Press 1961

References

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