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Influenza vaccination with live-attenuated and inactivated virus-vaccines during an outbreak of disease*

Published online by Cambridge University Press:  15 May 2009

G. Rocchi ,
G. Ragona ,
C. Piga ,
A. Pelosio ,
A. Volpi ,
S. Vella ,
N. Legniti  and
A. De Felici
G. Rocchi
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
G. Ragona
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
C. Piga
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
A. Pelosio
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
A. Volpi
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
S. Vella
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
N. Legniti
Affiliation:
Servizio di Sanità dell'esercito, Italy
A. De Felici
Affiliation:
Central Laboratory, ‘Lazzaro Spallanzani’ Hospital, Rome
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Immunization procedures with live attenuated and inactivated vaccines were carried out on a group of young recruits at the beginning of an outbreak of infection due to an A/Victoria/3/75-related virus strain, which occurred in February 1977 in a military camp. A retrospective investigation on protection from clinical influenza was then performed in order to investigate whether immunization with live virus vaccines, administered at the beginning of an epidemic, could provide early protection from the disease. In the course of the two weeks following vaccination, laboratory-confirmed clinical influenza cases occurred in 4 subjects among the 110 volunteers of the control group which received placebo, and in 8, 7 and 4 subjects respectively of the 3 groups of about 125 individuals, each of which received one of the following vaccine preparations: (a), live attenuated A/Victoria/3/75 influenza virus oral vaccine, grown on chick embryo kidney culture; (b), live attenuated nasal vaccine, a recombinant of A/Puerto Rico/8/34 with A/Victoria/3/75 virus; and (c), inactivated A/Victoria/3/75 virus intramuscular vaccine. These data do not support the hypothesis that, during an epidemic of infection, early protection from clinical influenza can be achieved through immunization with live attenuated or inactivated influenza virus vaccines, in spite of the high immunizing capability of the vaccine preparations.

Type
Research Article
Information
Journal of Hygiene , Volume 83 , Issue 3 , December 1979 , pp. 383 - 390
Copyright
Copyright © Cambridge University Press 1979

References

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