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Influenza infections during pregnancy in the mouse

Published online by Cambridge University Press:  15 May 2009

K. Williams  and
J. S. Mackenzie
K. Williams
Affiliation:
University Department of Microbiology, Perth Medical Centre, Nedlands, Western Australia6009
J. S. Mackenzie
Affiliation:
University Department of Microbiology, Perth Medical Centre, Nedlands, Western Australia6009
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Summary

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The effect of a sublethal dose (0·5 LD 50) of influenza A/WSN (H0N1) administered intranasally in the 1st and 3rd weeks of pregnancy was studied in C3H inbred mice. Maternal and neonatal mortality rates were significantly increased by infections in the 3rd week of pregnancy, but not in the 1st week. Infections during the last part of the 1st week significantly depressed the growth rate of neonates. No evidence of viraemia, transplacental transmission or congenital malformations were observed from infections during either week. The results are discussed in terms of a possible model for human influenza infections during pregnancy to determine the potential risks to the mother, fetus and neonate.

Type
Research Article
Information
Journal of Hygiene , Volume 79 , Issue 2 , October 1977 , pp. 249 - 257
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Adams, J. M., Heath, H. D., Imagawa, D. T., Jones, M. H. & Shear, H. H. (1956). Viral infections in the embryo. American Journal of Diseases of Children 92, 109–14.Google ScholarPubMed
Coffey, V. P. & Jessop, W. J. E. (1959). Maternal influenza and congenital deformities. A prospective study. Lancet ii, 935–8.CrossRefGoogle Scholar
Finn, R., St Hill, C. A., Govan, A. J., Ralfs, I. G., Gurney, F. J. & Denye, V. (1972). Immunological responses in pregnancy and survival of fetal homograft. British Medical Journal iii, 150–2.CrossRefGoogle Scholar
Freeman, D. W. & Barno, A. (1959). Deaths from Asian influenza associated with pregnancy. American Journal of Obstetrics and Gynecology 78, 1172–5.CrossRefGoogle ScholarPubMed
Greenberg, M., Jacobziner, H., Pakter, J. & Weisl, B. A. G. (1958). Maternal mortality in the epidemic of Asian influenza, New York City, 1957. American Journal of Obstetrics and Gynecology 76, 897–902.CrossRefGoogle ScholarPubMed
Hakosalo, J. & Saxen, L. (1971). Influenza epidemic and congenital defects. Lancet ii, 1346–7.CrossRefGoogle Scholar
Hamburger, V. & Habel, K. (1947). Teratogenic and lethal effects of influenza A and mumps viruses on early chick embryos. Proceedings of the Society for Experimental Biology and Medicine 66, 608–17.CrossRefGoogle ScholarPubMed
Hamre, D., Appel, J. & Loosli, C. G. (1955). Viraemia in mice with pulmonary influenza A virus infection. Journal of Laboratory and Clinical Medicine 47, 182–93.Google Scholar
Hashimi, A., Carruthers, M. M., Wolf, P. & Lerner, A. M. (1966). Congenital infections with reovirus. Journal of Experimental Medicine 124, 33–46.CrossRefGoogle Scholar
Harris, J. W. (1919). Influenza occurring in pregnant women. A statistical study of thirteen hundred and fifty cases. Journal of the American Medical Association 72, 978–80.CrossRefGoogle Scholar
Heath, H. D., Shear, H. H., Imagawa, D. T., Jones, M. H. & Adams, J. M. (1956). Teratogenic effects of Herpes simplex, vaccinia, influenza A (NWS), and distemper virus infections on early chick embryos. Proceedings of the Society for Experimental Biology and Medicine 92, 675–82.CrossRefGoogle Scholar
Hers, J. F. P. & Mulder, J. (1961). Broad aspects of the pathology and pathogenesis of human influenza. American Review of Respiratory Diseases 83, Supplement, 84–9.Google Scholar
Khakpour, M., Saidi, A. & Naficy, K. (1969). Proved viraemia in Asian influenza (Hong Kong variant) during incubation period. British Medical Journal iv, 208–9.CrossRefGoogle Scholar
Leck, I. (1963). Incidence of malformations following influenza epidemics. British Journal of Preventive and Social Medicine 17, 70–80.Google ScholarPubMed
Leck, I. (1971). Further tests of the hypothesis that influenza in pregnancy causes malformations. HSMHA Health Reports 86, 265–9.CrossRefGoogle ScholarPubMed
Leck, I., Hay, S., Witte, J. J. & Greene, J. C. (1969). Malformations recorded on birth certificates following A2 influenza epidemics. Public Health Reports 84, 971–9.CrossRefGoogle ScholarPubMed
Lehmann, N. I. & Gust, I. D. (1971). Viraemia in influenza. A report of two cases. Medical Journal of Australia 2, 1166–9.CrossRefGoogle ScholarPubMed
London, W. T., Fuccillo, P. A., Sever, J. L. & Kent, S. G. (1975). Influenza virus as a teratogen in rhesus monkeys. Nature, London 255, 483–4.CrossRefGoogle ScholarPubMed
Mackenzie, J. S. & Houghton, M. (1974). Influenza infections during pregnancy: association with congenital malformations and with subsequent neoplasms in children, and potential hazards of live virus vaccines. Bacteriological Reviews 38, 356–70.CrossRefGoogle ScholarPubMed
Mims, C. A. (1968). Pathogenesis of viral infections of the fetus. Progress in Medical Virology 10, 194–237.Google ScholarPubMed
Naficy, K. (1963). Human influenza infections with proved viraemia: report of a case. New England Journal of Medicine 269, 964–6.CrossRefGoogle ScholarPubMed
Purtillo, D. T., Hallgren, H. M. & Yunis, E. J. (1972). Depressed maternal lymphocyte response to phytohaemagglutinin in human pregnancy. Lancet i, 769–71.CrossRefGoogle Scholar
Robertson, G. G., Williamson, A. P. & Blattner, R. J. (1960). Origin of myeloschisis in chick embryos infected with influenza A virus. Yale Journal of Biology and Medicine 32, 449–63.Google ScholarPubMed
Seim, R. A., Ly, H., Imagawa, P. T. & Adams, J. M. (1960). Influenza virus infections in pregnant mice. Journal of Neuropathology and Experimental Neurology 19, 125–9.CrossRefGoogle Scholar
Straub, M. (1937). The microscopical changes in the lungs of mice infected with influenza virus. Journal of Pathology and Bacteriology 45, 75–8.CrossRefGoogle Scholar
Sweet, C., Toms, G. L., Kingsman, S. M. & Smith, H. (1976). The pregnant ferret as a model for studying influenza virus infection in utero. Proceedings of the Society for General Microbiology 3, 113–14.Google Scholar
Widelock, D., Csizmas, L. & Klein, S. (1963). Influenza, pregnancy, and fetal outcome. Public Health Reports 78, 1–11.CrossRefGoogle ScholarPubMed
Wilson, M. G. & Stein, A. M. (1969). Teratogenic effects of Asian influenza. Journal of the American Medical Association 171, 638–41.CrossRefGoogle Scholar
Yawn, D. H., Pyeatte, J. C., Joseph, S. M., Eichler, S. L. & Garcia-Bunuel, R. (1971). Transplacental transfer of influenza virus. Journal of the American Medical Association 216, 1022–3.CrossRefGoogle ScholarPubMed