Influenza A among community-dwelling elderly persons in Leicestershire during winter 1993–4; cigarette smoking as a risk factor and the efficacy of influenza vaccination

K. G. NICHOLSON; J. KENT; V. HAMMERSLEY

doi:10.1017/S095026889900271X

Abstract

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In a prospective study of community-dwelling people 60–90 years of age, we examined the coverage of influenza vaccine during 1992–3 and 1993–4, the efficacy of vaccination in reducing serologically-confirmed clinical episodes of influenza A during 1993, and the effect of cigarette smoking. During 1992 and 1993, influenza vaccine was given to 106/215 (49%) and 120/204 (59%) people with risk conditions, and 84/225 (37%) and 103/235 (44%) without risk conditions. Influenza vaccination and general practitioner consultations during 1992 were independent predictors of vaccination in 1993, but current smoking was a negative predictor. Of 209 unimmunized people, 8/35 (23%) smokers had clinical influenza as compared with 11/174 (6 %) non-smokers (OR 4·4, 95% CI 1·6 to 11·9). Of 371 non-smokers, 1/197 (0·5%) vaccinees had influenza as compared with 11/174 (6 %) non-vaccinees (OR 0·075, 95% CI 0·587 to 0·009). No cases of influenza occurred among 21 current smokers who were vaccinated.

Crossref Citations

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Nicholson, Karl G Wood, John M and Zambon, Maria 2003. Influenza. The Lancet, Vol. 362, Issue. 9397, p. 1733.

Evans, Meirion R. and Watson, Phil A. 2003. Why do older people not get immunised against influenza?. Vaccine, Vol. 21, Issue. 19-20, p. 2421.

Jiménez, Rodrigo Larrauri, Amparo Carrasco, Pilar Esteban, Jesús Gómez-López, Luis Ignacio and Gil, Ángel 2003. Influenza coverages in Spain and vaccination-related factors in the subgroup aged 50–64 years. Vaccine, Vol. 21, Issue. 25-26, p. 3550.

Andrew, Melissa K McNeil, Shelly Merry, Heather and Rockwood, Kenneth 2004. Rates of influenza vaccination in older adults and factors associated with vaccine use: A secondary analysis of the Canadian Study of Health and Aging. BMC Public Health, Vol. 4, Issue. 1,

Carrat, Fabrice Deshayes, Juliette Goderel, Isabelle Pannetier, Gregory Lazarovici, Céline and Valleron, Alain-Jacques 2004. Factors associated with intensity of symptoms in patients seeking medical advice for flu. International Congress Series, Vol. 1263, Issue. , p. 308.

Jefferson, T Rivetti, D Rivetti, A Rudin, M Di Pietrantonj, C and Demicheli, V 2005. Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. The Lancet, Vol. 366, Issue. 9492, p. 1165.

Nichol, Kristin L 2005. Influenza Vaccination in the Elderly. Drugs & Aging, Vol. 22, Issue. 6, p. 495.

Jiménez-García, Rodrigo Hernández-Barrera, Valentín Carrasco Garrido, Pilar del Pozo, Silvia Vázquez-Fernández and de Miguel, Ángel Gil 2006. Influenza vaccination among cardiovascular disease sufferers in Spain: Related factors and trend, 1993–2003. Vaccine, Vol. 24, Issue. 23, p. 5073.

Chi, Ru‐Chien Reiber, Gayle E. and Neuzil, Kathleen M. 2006. Influenza and Pneumococcal Vaccination in Older Veterans: Results from the Behavioral Risk Factor Surveillance System. Journal of the American Geriatrics Society, Vol. 54, Issue. 2, p. 217.

Rodríguez-Rodríguez, M.I. Gatón del Amo, M. Robles-Marinas, V. and Rubio-Domínguez, J. 2006. Factores determinantes de vacunación antigripal en mayores de 65 años. Atención Primaria, Vol. 37, Issue. 7, p. 381.

Hirdes, John P. Dalby, Dawn M. Steel, R. Knight Carpenter, G. Iain Bernabei, Roberto Morris, John N. and Fries, Brant E. 2006. Predictors of Influenza Immunization Among Home Care Clients in Ontario. Canadian Journal of Public Health, Vol. 97, Issue. 4, p. 335.

Rivetti, Daniela Jefferson, Tom Thomas, Roger E Rudin, Melanie Rivetti, Alessandro Di Pietrantonj, Carlo Demicheli, Vittorio and Rivetti, Daniela 2006. Cochrane Database of Systematic Reviews.

Robbins, Clinton S. Bauer, Carla M. T. Vujicic, Neda Gaschler, Gordon J. Lichty, Brian D. Brown, Earl G. and Stämpfli, Martin R. 2006. Cigarette Smoke Impacts Immune Inflammatory Responses to Influenza in Mice. American Journal of Respiratory and Critical Care Medicine, Vol. 174, Issue. 12, p. 1342.

Hara, Megumi Sakamoto, Tatsuhiko and Tanaka, Keitaro 2006. Effectiveness of influenza vaccination in preventing influenza-like illness among community-dwelling elderly: Population-based cohort study in Japan. Vaccine, Vol. 24, Issue. 27-28, p. 5546.

Mayo Montero, Elga Hernández-Barrera, Valentín Carrasco-Garrido, Pilar Gil de Miguel, Ángel and Jiménez-García, Rodrigo 2007. Influenza vaccination among persons with chronic respiratory diseases: Coverage, related factors and time-trend, 1993–2001. Public Health, Vol. 121, Issue. 2, p. 113.

Taylor, E. 2007. Project based approach to increasing uptake of influenza vaccine in an underachieving GP practice. British Journal of Infection Control, Vol. 8, Issue. 5, p. 8.

Looijmans-van den Akker, I. van den Heuvel, P.M. Verheij, Th.J.M. van Delden, J.J.M. van Essen, G.A. and Hak, E. 2007. No intention to comply with influenza and pneumococcal vaccination: Behavioural determinants among smokers and non-smokers. Preventive Medicine, Vol. 45, Issue. 5, p. 380.

Bauer, Carla M.T. DeWitte-Orr, Stephanie J. Hornby, Kyle R. Zavitz, Caleb C.J. Lichty, Brian D. Stämpfli, Martin R. and Mossman, Karen L. 2008. Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells. Journal of Interferon & Cytokine Research, Vol. 28, Issue. 3, p. 167.

Mian, M. Firoz Stämpfli, Martin R. Mossman, Karen L. and Ashkar, Ali A. 2009. Cigarette smoke attenuation of poly I:C-induced innate antiviral responses in human PBMC is mainly due to inhibition of IFN-β production. Molecular Immunology, Vol. 46, Issue. 5, p. 821.

Pearson, William S. Dube, Shanta R. Ford, Earl S. and Mokdad, Ali H. 2009. Influenza and pneumococcal vaccination rates among smokers: Data from the 2006 Behavioral Risk Factor Surveillance System. Preventive Medicine, Vol. 48, Issue. 2, p. 180.

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Influenza A among community-dwelling elderly persons in Leicestershire during winter 1993–4; cigarette smoking as a risk factor and the efficacy of influenza vaccination

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