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Infection with influenza A H1N1: 2. The effect of past experience on natural challenge

Published online by Cambridge University Press:  19 October 2009

J. R. Davies ,
E. A. Grilli  and
A. J. Smith
J. R. Davies
Affiliation:
Influenza Research Unit, PHLS Laboratory, St Lukes Hospital, Guildford, Surrey GU1 3NT
E. A. Grilli
Affiliation:
Influenza Research Unit, PHLS Laboratory, St Lukes Hospital, Guildford, Surrey GU1 3NT
A. J. Smith
Affiliation:
Influenza Research Unit, PHLS Laboratory, St Lukes Hospital, Guildford, Surrey GU1 3NT
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Following its reintroduction in 1978 influenza A H1N1 spread widely in the child population. By the autumn of 1979, 75% of 11-year olds entering a boys' boarding school had detectable antibody. The protective effect of previous experience could be assessed during two outbreaks in the school. In the first outbreak in 1979, 90% of those known to have been infected in the previous year were protected against reinfection. In 1983 after strains of the H1N1 subtype had undergone antigenic drift a large outbreak occurred. It was estimated that past infection conferred protection against clinical influenza in 55%. Where past infection resulted in the presence of antibody which reacted with the outbreak strain the attack rate was further reduced. A large number of sub-clinical infections was detected in all groups.

Type
Research Article
Information
Journal of Hygiene , Volume 96 , Issue 2 , April 1986 , pp. 345 - 352
Copyright
Copyright © Cambridge University Press 1986

References

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