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Infection with influenza A H1N1: 1. Production and persistence of antibody

Published online by Cambridge University Press:  19 October 2009

E. A. Grilli ,
J. R. Davies  and
A. J. Smith
E. A. Grilli
Affiliation:
Influenza Research Unit, PHLS Laboratory, St Lukes Hospital, Guildford, Surrey GU1 3NT
J. R. Davies
Affiliation:
Influenza Research Unit, PHLS Laboratory, St Lukes Hospital, Guildford, Surrey GU1 3NT
A. J. Smith
Affiliation:
Influenza Research Unit, PHLS Laboratory, St Lukes Hospital, Guildford, Surrey GU1 3NT
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Three outbreaks of influenza caused by influenza A H1N1 occurred in a boys' boarding school in 1978, 1979 and 1983. The serological response to infection with variants of the H1N1 virus was studied by radial haemolysis and haemagglutination inhibition after primary infection and reinfection. The persistence of this antibody was also studied. Infection in 1978 resulted in the production of persistent antibody to both the haemagglutinin and neuraminidase of the homotypic strain. Antibody which cross-reacted with later variants of the virus was less frequently produced, the peak response was delayed and such antibody persisted less well. Infection in 1979 resulted in a similar response to that observed in 1978 after primary infection. Reinfection resulted in a broad response in all cases. In 1983 all infected boys produced antibody which reacted with the homotypic strain but only approximately one-third of primary infections produced antibody which reacted with the A/USSR/92/77 strain. The neuraminidase of the A/USSR strain failed to detect one third of the primary infections. Reinfection again resulted in a broad response.

Type
Research Article
Information
Journal of Hygiene , Volume 96 , Issue 2 , April 1986 , pp. 335 - 343
Copyright
Copyright © Cambridge University Press 1986

References

REFERENCES

Chakraverty, P. (1980). Comparison of haemagglutination-inhibition and single-radialhaemolysis techniques for the detection of antibodies to influenza B virus. Archives of Virology 63, 285–289.CrossRefGoogle ScholarPubMed
Chakraverty, P., Cunningham, P. & Pereira, M. S. (1982). The return of the historic influenza A H1N1 virus and its impact on the population of the United Kingdom. Journal of Hygiene 89, 89–100.CrossRefGoogle ScholarPubMed
Communicable Disease Surveillance Centre (1978). Influenza. British Medical Journal 1, 311.Google Scholar
Davies, J. R., Grilli, E. A. & Smith, A. J. (1984). Influenza A: infection and reinfection. Journal of Hygiene 92, 125–127.CrossRefGoogle Scholar
Davies, J. R., Grilli, E. A. & Smith, A. J. (1986). Infection with influenza A H1N1. 2. The effect of past experience on natural challenge. Journal of Hygiene 96, 345–352.CrossRefGoogle ScholarPubMed
Davies, J. R., Smith, A. J., Grilli, E. A. & Hoskins, T. W. (1982). Christ's Hospital 1978–79: an account of two outbreaks of influenza A H1N1. Journal of Infection 5, 151–156.CrossRefGoogle Scholar
Grilli, E. A. & Smith, A. J. (1983). The use of a radial haemolysis test for neuraminidase antibodies in the diagnosis of influenza A infection. Journal of Hygiene 91, 147–156.CrossRefGoogle ScholarPubMed
Shortridge, K. F. & Osmund, I. (1978). H1N1 influenza in Hong Kong. Lancet i, 322.CrossRefGoogle Scholar
Stranneoård, O., Grillner, L. & Lindberg, I. M. (1975). Haemolysis-in-gel test for the demonstration of antibodies to rubella virus. Journal of Clinical Microbiology 1, 491–494.CrossRefGoogle Scholar
Zhdanov, V. M., Lvov, D. K., Zakstelskaya, L. Ya., Yakhno, M. A., Isachenko, V. I., Braude, N. A., Reznik, V. I., Pysina, T. V., Andreyev, V. P. & Podchernyaeva, R. Ya. (1978). Return of epidemic A1 (H1N1) influenza virus. Lancet i, 294–295.CrossRefGoogle Scholar