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Incidence and risk factors of HCV and HIV infections in a cohort of intravenous drug users in the North and East of France

Published online by Cambridge University Press:  09 July 2004

D. LUCIDARME ,
A. BRUANDET ,
D. ILEF ,
J. HARBONNIER ,
C. JACOB ,
A. DECOSTER ,
C. DELAMARE ,
C. CYRAN ,
A.-F. VAN HOENACKER  and
D. FRÉMAUX
...Show all authors
D. LUCIDARME
Affiliation:
Service de Pathologie Digestive, Centre Hospitalier Saint Philibert, 115 rue du Grand But – BP 249, 59462 Lomme cedex, France
A. BRUANDET
Affiliation:
Institut de Veille Sanitaire, 14 rue du Val d'Osne, 94415 Saint Maurice cedex, France
D. ILEF
Affiliation:
Cellule InterRégionale d'Epidémiologie de Nord-Picardie, 62 boulevard de Belfort – BP 605, 59024 Lille cedex, France
J. HARBONNIER
Affiliation:
Centre Boris Vian, 19 bis avenue Kennedy, 59800 Lille, France
C. JACOB
Affiliation:
Centre Baudelaire, 46 rue Serpenoise, 57000 Metz, France
A. DECOSTER
Affiliation:
Laboratoire de Microbiologie, Centre Hospitalier Saint Philibert, 115 rue du Grand But – BP 249, 59462 Lomme cedex, France
C. DELAMARE
Affiliation:
Laboratoire de Microbiologie, Centre Hospitalier, rue de Friscaty, 57100 Thionville, France
C. CYRAN
Affiliation:
Le Square, 31 rue Jean Souvraz, 62300 Lens, France
A.-F. VAN HOENACKER
Affiliation:
Le Cèdre Bleu, avenue de Bretagne, 59000 Lille, France
D. FRÉMAUX
Affiliation:
Drogue 80, 51 Mail Albert Premier, 80000 Amiens, France
P. JOSSE
Affiliation:
UFATT, 22 bis rue de Malzeville, 54000 Nancy, France
J. EMMANUELLI
Affiliation:
Institut de Veille Sanitaire, 14 rue du Val d'Osne, 94415 Saint Maurice cedex, France
Y. LE STRAT
Affiliation:
Institut de Veille Sanitaire, 14 rue du Val d'Osne, 94415 Saint Maurice cedex, France
J.-C. DESENCLOS
Affiliation:
Institut de Veille Sanitaire, 14 rue du Val d'Osne, 94415 Saint Maurice cedex, France
B. FILOCHE
Affiliation:
Service de Pathologie Digestive, Centre Hospitalier Saint Philibert, 115 rue du Grand But – BP 249, 59462 Lomme cedex, France
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Abstract

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In order to evaluate the incidence and risk factors of infection by hepatitis C virus (HCV) among injecting drug users (IDUs), we conducted a prospective cohort study of HCV- and human immunodeficiency virus (HIV)-negative IDUs in the North and East of France. A total of 231 HCV and HIV IDUs who had injected drugs at least once in their lifetime were followed up every 3 months over a 12-month period. Serum anti-HCV and anti-HIV were tested at inclusion in the study and at the end of the follow-up. Data on injecting practices were collected at inclusion and at each visit. Of the 231 participants included, 165 (71·4%) underwent a final HCV and HIV serum test. The incidence was nil for HIV infection and 9/100 person-years (95% CI 4·6–13·4) for HCV infection. In a multivariable analysis, we found that syringe and cotton sharing were the only independent predictive factors of HCV seroconversion.

Type
Research Article
Information
Epidemiology & Infection , Volume 132 , Issue 4 , August 2004 , pp. 699 - 708
Copyright
2004 Cambridge University Press