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The importance of antineuraminidase antibodies in resistance to influenza A and immunologic memory for their synthesis

Published online by Cambridge University Press:  19 October 2009

A. N. Naikhin ,
I. M. Tsaritsina ,
E. V. Oleinikova ,
L. G. Syrodoeva ,
N. L. Korchanova ,
G. M. Denisov  and
Ya.S. Shvartsman
A. N. Naikhin
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
I. M. Tsaritsina
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
E. V. Oleinikova
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
L. G. Syrodoeva
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
N. L. Korchanova
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
G. M. Denisov
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
Ya.S. Shvartsman
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
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Eight hundred and seventy-seven sera from 360 adults aged 18–50 who were under permanent observation from October 1980 to March 1981 have been studied by haemagglutination-inhibition (HI) and erythrocyte elution-inhibition (EI) tests – a simplified method of antineuraminidase antibody titration. It was demonstrated in some subjects infected with influenza A H1N1 and H3N2 viruses that the antibody rise was to one of the surface antigens only – haemagglutinin or neuraminidase. These subjects made up 5·2–25·8% of all examinees. The protective effect of antibodies to neuraminidase was similar to that of antihaemagglutinins. Interaction of both types of antibodies was observed in protection against the disease. Data have been obtained on the influence of antineuraminidase antibodies in decreasing the severity of natural infection with influenza A.

A study of heterologous immunologic responses to haemagglutinin and neuraminidase among persons immunized with live influenza A H1N1 and H3N2 vaccines and among children naturally infected with influenza A H3N2 demonstrated the presence of immunologic memory for antineuraminidase antibody synthesis. Thus, the suggestion of a common antigenic structure for neuraminidase Nl and N2 is made.

Type
Research Article
Information
Journal of Hygiene , Volume 91 , Issue 1 , August 1983 , pp. 131 - 138
Copyright
Copyright © Cambridge University Press 1983

References

REFERENCES

Appleyard, G. & Oram, J. D. (1977). The assay of influenza anti-neuraminidase activity by an elution inhibition technique. Journal of General Virology 34, 137–144.CrossRefGoogle Scholar
Aymard, M. (1976). Influenza neuraminidaseantigenicvariantsand the roleof anti-neuraminidase antibodies. In Influenza Prophylaxis and Treatment, L. 17–38.Google Scholar
Gorev, N. E., Titova, T. S. & Korovina, G. I. (1977). Study of protecting role of antibodies to influenza surface antigens in experimental influenza infection. In Problems of Influenza and Acute Respiratory Diseases, L. 85–92.Google Scholar
Francis, T., Davenport, P.M. & Hennkssy, A. B. (1953). A serological recapitulation of human infection with different strains of influenza virus. Transactions of the Association of American Physicians 66, 231–240.Google ScholarPubMed
Kilbourne, E. D. (1975). The Influenza Viruses and Influenza. New York – San Francisco – London: Academic Press.Google ScholarPubMed
Milovidova, N. J., Porubel, L. A., Ginsburg, V. P. & Gendon, Yu. Z. (1974). Antigenic and immunogenicactivityofvirion componentsof influenza viruses. Prolrtetnsof Virology 6, 683–688.Google Scholar
Molibog, E. V., Konstantinov-Zibelist, I., Shtarke, G. & Zakstelskaya, L. Ya. (1979). Strain specificity of anti-neuraminidase antibodies of serotypes H2 of influenza virus strains in convalescents. Problems of Virology 6, 631–634.Google Scholar
Monto, A. S. & Kendal, A. P. (1973). Effect of neuraminidnso antibody on Hong Kong influenza. Lancet no 7804, 623–625.CrossRefGoogle Scholar
Murphy, B. R., Kasel, J. A. & Channock, R. M. (1972). Association of serum antineuraminidase antibody with resistance to influenza in man. New England Journal of Medicine 286, 1329–1332.CrossRefGoogle ScholarPubMed
Naikhin, A. N., Topuria, N. V. & Denisov, G. M. (1980). Role of anti-neuraminidase antibodies in human immunologic response to immunisation with live vaccines of type A. Microbiology Journal, 42, 642–645.Google Scholar
Naikhin, A. N., Topuria, N. V., Ismagulov, A. T., Denisov, G. M., Tsaritsina, I. M., Gorev, N. E. & Ivannikov, Yu. G. (1981). Complex study of population immunity to three influenza A antigens. Journal of Microbiology, Epidemiology and Immunobiology 2, 77–81.Google Scholar
Nobuhisa, J., Takado, O., Sizo, A., Mitsurek, K. & Nakao, J. (1979). Effect of specific immunity to viral neuraminidase on subsequent influenza virus infection in man. Microbiology and Immunology 23, 565–567.Google Scholar
Potter, C. W. & Oxford, J. S. (1979). Determinants of immunity to influenza infection in man. British Medical Bulletin 35, 69–75.CrossRefGoogle ScholarPubMed
Rott, R., Becht, H. & Orlich, M. (1974). The significance of influenza virus neuraminidase in immunity. Journal of General Virology 22, 35–41.CrossRefGoogle ScholarPubMed
Schulman, J. K., Ehakpour, M. K. & Kilbourne, E. D. (1908). Protective effect of specific immunity to viral neuraminidase on influenza virus infection of mice. Journal of Virology 2, 778–786.CrossRefGoogle Scholar
Topuria, N. V., Naikhin, A. N. & Denisov, G. M. (1979). Use of modified erythrocytes elution inhibition test methods (EIT) for detection of anti-neuraminidase antibodies in influenza infection. Proceedings of Academy of Sciences of Georgian Republic, Biological series 5, 357–361.Google Scholar
World Health Organisation (1959). Expert Committee on Respiratory Virus Diseases. World Health Organisation Technical Report Series, pp. 64–75.Google Scholar