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The immunoglobulin M response to rubella vaccine in young adult women

Published online by Cambridge University Press:  19 October 2009

P. P. Mortimer ,
J. M. B. Edwards ,
A. D. Porter ,
R. S. Tedder  and
J. Haslehurst
P. P. Mortimer
Affiliation:
PHLS Virus Reference Laboratory, Colindale Avenue, London NW9 5HT
J. M. B. Edwards
Affiliation:
PHLS Virus Reference Laboratory, Colindale Avenue, London NW9 5HT
A. D. Porter
Affiliation:
PHLS Virus Reference Laboratory, Colindale Avenue, London NW9 5HT
R. S. Tedder
Affiliation:
Department of Virology, Middlesex Hospital Medical School, London W1
J. Haslehurst
Affiliation:
Health Services, Marks and Spencer, Michael House, London W1A 1DN
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Summary

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Rubella vaccination histories were taken from 333 young women working in the head office of a retail organization: 29% said they had had vaccine and 47% said they had not. The remainder did not know. Forty-six per cent of those ≤ 25 years old (who should have been offered vaccine at school), and 6% of those > 25 years old, said they had been vaccinated. When screened for immunity to rubella by radial haemolysis (RH) 3% had a low level of antibody (< 15 i.u./ml) and 11% had no antibody. After immunization with Cendevax the specific rubella IgM response was measured by an IgM antibody capture radioimmunassay (MACRIA). It was only detectable in the group without RH antibody, and was present in 26/31 of them. The Ig M response to Cendevax was strongest in specimens taken 20–39 days after immunization, but in 10 out of 11 cases tested was still present at around 71 days. The specific Ig M responses to Cendevax were very similar to those in women given Almevax in an earlier study, when measured in parallel tests.

Taking both vaccines together, specific Ig M was present in 35 out of 36 vaccinees without pre-existing antibody tested between 40 and 77 days post-immunization. Detection of specific IgM by MACRIA would therefore be an effective means of determining susceptibility retrospectively in rubella vaccinees found to be pregnant.

Type
Research Article
Information
Journal of Hygiene , Volume 92 , Issue 3 , June 1984 , pp. 277 - 283
Copyright
Copyright © Cambridge University Press 1984

References

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