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Immunoglobulin G, A and M response to influenza vaccination in different age groups: effects of priming and boosting

Published online by Cambridge University Press:  19 October 2009

Walter E. P. Beyer ,
Jos T. M. Van Der Logt ,
Ruud van Beek  and
Nic Masurel
Walter E. P. Beyer
Affiliation:
Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam, The Netherlands
Jos T. M. Van Der Logt
Affiliation:
Department of Medical Microbiology, University of Nijmegen, The Netherlands
Ruud van Beek
Affiliation:
Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam, The Netherlands
Nic Masurel
Affiliation:
Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam, The Netherlands
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Fifty volunteers, treated with an inactivated trivalent influenza vaccine containing A/Bangkok/1/79 (H3N2), A/Brazil/11/78 (H1N1) and B/Singapore/222/79 virus, were subdivided according to the estimated first exposure to influenza in their lifetime (priming) and the presence of antibodies against the vaccine components in the pre-vaccination sera. The isotypic antibody response (IgG, IgA, IgM) was determined by means of an antibody capture haemadsorption immunosorbent technique. For all three vaccine components, previously seropositive subjects produced antibodies of the IgG- and IgA-class more frequently than previously seronegative persons. Subjects primed to one of the influenza A subtypes showed more IgG and IgA responses in comparison with those unprimed (prime-effect). In contrast, IgM antibodies occurred in only 19 and 11% of primed, but in 59 and 54% of unprimed subjects, for A (H3N2) and A (HlNl), respectively. The incidence of IgM titre rises was not influenced by the prevaccination state. However, the mean magnitude of anti-A(H1N1)-IgM titre rises was greater in those previously seronegative. The concepts of primary and reinfection and of ‘original antigenic sin’ are discussed, and it is suggested that age and, if possible, serological state prior to antigen-exposure should be taken into account when studying isotypic antibody responses after influenza infection or vaccination.

Type
Research Article
Information
Journal of Hygiene , Volume 96 , Issue 3 , June 1986 , pp. 513 - 522
Copyright
Copyright © Cambridge University Press 1986

References

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