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Immunoglobulin A antibodies directed against Campylobacter jejuni flagellin present in breast–milk

Published online by Cambridge University Press:  15 May 2009

I. Nachamkin ,
S. H. Fischer ,
X.-H. Yang ,
O. Benitez  and
A. Cravioto
I. Nachamkin
Affiliation:
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104–4283
S. H. Fischer
Affiliation:
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104–4283
X.-H. Yang
Affiliation:
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104–4283
O. Benitez
Affiliation:
Departamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F. 04510, México
A. Cravioto
Affiliation:
Departamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F. 04510, México
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We studied the relationship between IgA anti–campylobacter flagellin antibodies in breast milk samples and protection of breastfed infants living in a rural Mexican village from campylobacter infection. There were fewer episodes of campylobacter infection (symptomatic and asymptomatic combined) in infants breastfed with milk containing specific anti-flagellin antibodies (1.2/child/year, 95% CI 0.6–1.8) versus non–breastfed children (3.3/child/year, 95% CI 1.8–4.8; P < 0.01). Infants breastfed with milk that was antiflagellin antibody negative by ELISA also had fewer episodes of infection compared with non-breastfed children, but the difference did not reach statistical significance (1.8/child/year, 95% CI 0.7–3.0 versus 3.3/child/year, 95% CI 1.8–4.8, P > 0.05). Breastfeeding has a protective effect against campylobacter infection and is associated with the presence of specific antibodies directed against campylobacter flagellin.

Type
Research Article
Information
Epidemiology & Infection , Volume 112 , Issue 2 , April 1994 , pp. 359 - 365
Copyright
Copyright © Cambridge University Press 1994

References

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