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The immunizing potency of alcohol-killed and alcohol-preserved typhoid vaccine after storage for ten Years

Published online by Cambridge University Press:  15 May 2009

A. Felix  and
E. S. Anderson
A. Felix
Affiliation:
From the Central Enteric Reference Laboratory and Bureau, Public Health Laboratory Service (Medical Research Council), London
E. S. Anderson
Affiliation:
From the Central Enteric Reference Laboratory and Bureau, Public Health Laboratory Service (Medical Research Council), London
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1. Alcohol-killed and alcohol-preserved typhoid vaccine retains its power of stimulating Vi- and O-antibody formation unimpaired during storage at 1–2° C. for at least 10 years.

2. The Vi antibody induced by immunization with the 10-year-old vaccine possesses full ‘functional efficacy’ in passive-immunity tests in mice.

3. The expiry date of this type of vaccine can be extended to a period of 10 years, provided the vaccine is kept in cold storage.

4. Alcoholized vaccine can serve as ‘standard vaccine’ in any future attempt at standardization of the potency of typhoid vaccine.

Type
Research Article
Information
Journal of Hygiene , Volume 49 , Issue 2-3 , June 1951 , pp. 288 - 298
Copyright
Copyright © Cambridge University Press 1951

References

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