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The immunization of mice and calves with gal E mutants of Salmonella typhimurium

Published online by Cambridge University Press:  15 May 2009

C. Wray ,
W. J. Sojka ,
J. A. Morris  and
W. J. Brinley Morgan
C. Wray
Affiliation:
Central Veterinary Laboratory, Weybridge, Surrey
W. J. Sojka
Affiliation:
Central Veterinary Laboratory, Weybridge, Surrey
J. A. Morris
Affiliation:
Central Veterinary Laboratory, Weybridge, Surrey
W. J. Brinley Morgan
Affiliation:
Central Veterinary Laboratory, Weybridge, Surrey
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Summary

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A galactose epimeraseless (gal E) mutant of Salmonella typhimurium was investigated in mice and calves for its suitability as a live vaccine. In mice, a very highly significant difference in the mortality rates was observed when vaccinated and non-vaccinated animals were challenged with virulent strains of S. typhimurium and S. dublin.

In calves, doses of 106 and above of gal E mutant injected subcutaneously provided highly significant protection both in terms of mortality and prevalence of symptoms when calves were challenged orally with S. typhimurium. However, there appeared to be a relation between the vaccine and the presence of renal lesions and before gal E mutants can be recommended, further work is necessary to determine the pathogenesis of these lesions.

Type
Research Article
Information
Journal of Hygiene , Volume 79 , Issue 1 , August 1977 , pp. 17 - 24
Copyright
Copyright © Cambridge University Press 1977

References

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