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The immune response to viruses in calves: II. The response in young calves

Published online by Cambridge University Press:  15 May 2009

C. J. Sanderson
C. J. Sanderson
Affiliation:
Department of Preventive Medicine, University of Queensland, St Lucia, Queensland, Australia
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Injections of virus in calves up to about 5 weeks of age caused either the production of both IgM and IgG, or the production of only IgG, or no detectable antibody. In all but one case priming for a secondary response occurred even in the absence of a detectable primary response. These results suggest that in the young calf immunological memory is more readily induced than IgG synthesis. IgM appeared by the 7th or 10th day, which was similar to the response in older calves. IgG was more variable in its appearances but was usually considerably delayed relative to the response in older calves. In general only low levels of IgM were formed in the primary response and it was virtually absent from the secondary responses. Higher levels of IgM were formed after reovirus inoculation than after Murray Valley encephalitis virus or Getah viruses. The delay in appearance of IgG was more pronounced in response to Getah than to reovirus or Murray Valley encephalitis virus. High levels of maternally derived passive antibody inhibited the development of an active response, although in one animal a response occurred in the presence of low levels of passive antibody.

Type
Original Articles
Information
Journal of Hygiene , Volume 66 , Issue 3 , September 1968 , pp. 461 - 470
Copyright
Copyright © Cambridge University Press 1968

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