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Human sera possess a limited antibody repertoire to influenza neuraminidase antigenic variants selected in vitro

Published online by Cambridge University Press:  19 October 2009

Anita Natali ,
P. F. Panizzi ,
C. Chezzi  and
J. S. Oxford
Anita Natali
Affiliation:
Institute of Microbiology, University of Parma, Italy
P. F. Panizzi
Affiliation:
Institute of Microbiology, University of Parma, Italy
C. Chezzi
Affiliation:
Institute of Microbiology, University of Parma, Italy
J. S. Oxford
Affiliation:
Division of Virology, National Institute for Biological Standards and Control, Hampstead, London NW3 6RB
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Summary

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Four antigenic variants of the neuraminidase (NA) of A/Texas/77 (H3N2) virus were selected using monoclonal antibody at a frequency of one variant in 105 parental virions. The antigenic variants failed to react serologically with the monoclonal antibody used for their selection in vitro. The antigenic variants failed also to react serologically with a proportion of sera from children and adults although all of the sera reacted with the parental A/Texas/77 virus. Thus, certain human sera have a restricted antibody repertoire to influenza NA antigen which might enable virus antigenic variants to avoid anti-NA antibody-mediated neutralization in nature.

Type
Research Article
Information
Journal of Hygiene , Volume 92 , Issue 2 , April 1984 , pp. 243 - 250
Copyright
Copyright © Cambridge University Press 1984

References

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