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Human herpesvirus-8 antibodies and DNA in HIV-1 infected patients in South Africa

Published online by Cambridge University Press:  23 December 2003

L. ALAGIOZOGLOU ,
L. MORRIS ,
H. BREDELL ,
D. J. MARTIN  and
F. SITAS
L. ALAGIOZOGLOU
Affiliation:
AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, University of the Witwatersrand, Johannesburg, South Africa
L. MORRIS
Affiliation:
AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, University of the Witwatersrand, Johannesburg, South Africa
H. BREDELL
Affiliation:
AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, University of the Witwatersrand, Johannesburg, South Africa
D. J. MARTIN
Affiliation:
AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, University of the Witwatersrand, Johannesburg, South Africa
F. SITAS
Affiliation:
Cancer Epidemiology Research Group and National Cancer Registry, National Health Laboratory Service, Department of Anatomical Pathology, University of the Witwatersrand, Johannesburg, South Africa
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Abstract

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HIV-infected individuals with high levels of IgG antibodies against human herpesvirus-8 (HHV-8) are at increased risk of developing Kaposi's sarcoma. The aim of this study was to measure the association between HHV-8 viraemia and IgG antibody responses (by immunofluorescence) in a group of 201 HIV-infected individuals attending outpatient clinics, 91 in-patients with AIDS and 87 HIV-infected patients admitted with Kaposi's sarcoma. Compared to HIV-infected outpatients, the adjusted odds ratio in relation to Kaposi's sarcoma was 15·4 (95% CI 4·4–54·2) in those with viraemia, 25·1 (95% CI 6·6–95·6) in those with a positive immunofluorescent signal and ∞ (lower exact CI 33·6) in those with a high immunofluorescent signal (all P trend <0·001). Among those without HHV-8 viraemia, 23% were IgG-positive, but only 5·5% had a high immunofluorescent signal. In those who were viraemic, 89·1% were IgG-positive, and 28·2% had a high immunofluorescent signal, suggesting viraemia is associated with high HHV-8 immunofluorescence IgG signal.

Type
Research Article
Information
Epidemiology & Infection , Volume 131 , Issue 3 , December 2003 , pp. 1125 - 1129
Copyright
2003 Cambridge University Press