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Hospital dispersion of Staphylococcus epidermidis isolates resistant to a fluoroquinolone, pefloxacin

Published online by Cambridge University Press:  15 May 2009

J. Etienne ,
Y. Brun ,
M. Billard  and
J. Fleurette
J. Etienne
Affiliation:
Centre National de Référence des Staphylocoques, Faculté de Médecine Alexis Carrel, rue Guillaume Paradin, 69372 Lyon Cédex 8, France
Y. Brun
Affiliation:
Centre National de Référence des Staphylocoques, Faculté de Médecine Alexis Carrel, rue Guillaume Paradin, 69372 Lyon Cédex 8, France
M. Billard
Affiliation:
12Hôpital Cardiologique, Pharmacie, BP Lyon Montchat, 69394 Lyon Cédex 3, France
J. Fleurette
Affiliation:
Centre National de Référence des Staphylocoques, Faculté de Médecine Alexis Carrel, rue Guillaume Paradin, 69372 Lyon Cédex 8, France
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Summary

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Since 1985. nosocomial infections have been frequently treated with a new fluoroquinolone, pefloxacin, at the Cardiological and Neurological Hospital in Lyon. From 1986 to 1988. the incidence of resistance of clinical Staphylococcus epidermidis strains to pefloxacin increased from 31 to 57%. Dispersion of these resistant strains in the hospital environment was recognized when they were detected on 22% of staff members' fingers (139 samples were investigated) and in 28% of the environmental samples (180 were investigated). There was an association between carriage rate and work place. Most of the pefloxacin-resistant S. epidermidis were resistant to oxacillin, gentamicin. erythromycin, cotrimoxazole and fosfomycin. Intensive use of pefloxacin selected multiresistant S. epidermidis which became ubiquitous in the hospital environment.

Type
Research Article
Information
Epidemiology & Infection , Volume 103 , Issue 3 , December 1989 , pp. 459 - 464
Copyright
Copyright © Cambridge University Press 1989

References

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