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HLA antigens and responses to rubella vaccination

Published online by Cambridge University Press:  15 May 2009

Gillian C. Harcourt ,
Jennifer M. Best ,
J. E. Banatvala  and
Lesley A. Kennedy
Gillian C. Harcourt
Affiliation:
Department of Virology, St Thomas' Hospital and Medical School, London SE1 7EH
Jennifer M. Best
Affiliation:
Department of Virology, St Thomas' Hospital and Medical School, London SE1 7EH
J. E. Banatvala
Affiliation:
Department of Virology, St Thomas' Hospital and Medical School, London SE1 7EH
Lesley A. Kennedy
Affiliation:
Tissue Typing Laboratory, Guy's Hospital, London SE1 9RT
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Attempts were made to correlate virus excretion, joint symptoms and antibody response with human leukocyte antigens (HLA) in seronegative adult women given attenuated rubella vaccine. No association was shown between HLA antigens of the A and B loci and excretion of either high or low titres of RA27/3 vaccine among 26 volunteers. However, virus excretion was influenced by such factors as the time of day at which specimens were collected and the method of virus isolation. Our study therefore failed to confirm the hypothesis that certain persons are good ‘spreaders’ of rubella virus and that this capacity is associated with HLA-A1 and B8.

The study of joint symptoms following vaccination with Cendehill, HPV77. DE-5, RA27/3 or To-336 vaccines showed no association between such symptoms and HLA antigens. However, joint symptoms occurred within 7 days of the onset of menstruation in 33 of 47 (70%) vaccinees (P < 0.01) and it is therefore suggested that hormonal factors must play a role. No association between HLA antigens and haemagglutination inhibition (HAI) antibody titres, 8 weeks after vaccination with RA27/3, was found amongst 34 volunteers.

Type
Research Article
Information
Journal of Hygiene , Volume 83 , Issue 3 , December 1979 , pp. 405 - 412
Copyright
Copyright © Cambridge University Press 1979

References

Best, J. M. & Banatvala, J. E. (1970). Studies on rubella strain variation by kinetic haemagglutination-inhibition tests. Journal of General Virology 9, 215.CrossRefGoogle ScholarPubMed
Best, J. M., Banatvala, J. E. & Bowen, J. M. (1974). New Japanese rubella vaccine: Comparative trials. British Medical Journal ii, 221.CrossRefGoogle Scholar
Black, F. L. (1966). Measles endemicity in insular populations: Critical community size and its evolutionary implication. Journal of Theoretical Biology 11, 207.CrossRefGoogle ScholarPubMed
Black, F. L. (1976). Measles. In Viral Infections of Humans. Epidemiology and Control ch. 13 (ed. Evans, A. S.), p. 297. John Wiley & Sons Ltd.CrossRefGoogle Scholar
Cockburn, W. C. (1969). World aspects of the epidemiology of rubella. American Journal of Diseases of Children 118, 112.Google ScholarPubMed
Cooper, L. Z., Matters, B., Rosenbaum, J. K. & Krugman, S. (1969). Experience with a modified rubella hemagglutination-inhibition antibody test. Journal of the American Medical Association 207, 89.CrossRefGoogle ScholarPubMed
Dausset, J. & Svejgaard, A. (1976). HLA and disease. Predisposition to disease and clinical implications. Editions Inserm, Paris.Google Scholar
Dowdle, W. R., Ferreira, W., De Salles Gomes, L. F., King, D., Kourany, M., Madalengoitia, J., Pearson, E., Swanston, W. H., Tosi, H. C. & Vilches, A. M. (1970). WHO collaborative study on the sero-epidemiology of rubella in Caribbean and middle and south American populations in 1968. Bulletin of the World Health Organization 42, 419.Google Scholar
Gale, J. L., Detels, R., Kim, K. S. W., Beasley, R. P. & Grayston, J. T. (1969). Epidemiology of rubella on Taiwan. American Journal of Diseases of Children 118, 143.Google ScholarPubMed
Griffiths, M. M., Spruance, S. L., Ogra, P. L., Thompson, G. R. & Dewitt, C. W. (1977). HLA and recurrent episodic arthropathy associated with rubella vaccination. Arthritis and Rheumatism 20, 1192.CrossRefGoogle ScholarPubMed
Halstead, S. B., Diwan, A. R. & Oda, A. I. (1969). Susceptibility to rubell among adolescents and adults in Hawaii. Journal of the American Medical Association 210, 1881.CrossRefGoogle Scholar
Honeyman, M. C., Dorman, D. C., Menser, M. A., Forrest, J. M., Guinan, J. J. & Clark, P. (1975). HL-A antigens in congenital rubella and the role of antigens 1 and 8 in the epidemiology of natural rubella. Tissue Antigens 5, 12.CrossRefGoogle ScholarPubMed
Honeyman, M. C. & Menser, M. A. (1974). Ethnicity is a significant factor in the epidemiology of rubella and Hodgkin's disease. Nature, London 251, 441.CrossRefGoogle ScholarPubMed
Kato, S., Kimura, M., Takakura, I., Sakakibara, T., Inouye, H. & Tsuji, K. (1978). Possible associations between HLA antigens and the immune responsiveness to attenuated rubella vaccine. Tissue Antigens 11, 475.CrossRefGoogle ScholarPubMed
Kono, R., Hibi, M., Hayakawa, Y. & Ishii, K. (1969). Experimental vertical transmission of rubella virus in rabbits. Lancet i, 343.CrossRefGoogle Scholar
Lang, D. J. (1975). The epidemiology of cytomegalovirus infections: Interpretation of recent observations. In ‘Infections of the fetus and the newborn infant’. Progress in Clinical and Biological Research 3, 35.Google Scholar
Pitts, O. M., Ravenel, J. M. & Finklea, J. F. (1969). Rubella immunity in Trinidad. American Journal of Epidemiology 89, 271.CrossRefGoogle ScholarPubMed
Potter, J. E., Banatvala, J. E. & Best, J. M. (1973). Interferon studies with Japanese and U.S. rubella virus strains. British Medical Journal i, 197.CrossRefGoogle Scholar
Rawls, W. E., Melnick, J. L., Bradstreet, C. M. P., Bailey, M., Ferris, A. A., Lehmann, N. I., Nagler, F. P., Furesz, J., Kono, R., Ohtawara, M., Halonen, P., Stewart, J., Ryan, J. M., Strauss, J., Zdrazilek, J., Leerhoy, J., Von Magnus, H., Sohier, R. & Ferreira, W. (1967). WHO collaborative study on the sero-epidemiology of rubella. Bulletin of the World Health Organization 37, 79.Google Scholar
Spencer, M. J., Cherry, J. D., Powell, K. R., Mickey, M. R., Terasaki, P. I., Marcy, S. M. & Sumaya, C. V. (1977). Antibody responses following rubella immunization analyzed by HLA and ABO types. Immunogenetics 4, 365.CrossRefGoogle Scholar
Sugishita, C., O'shea, S., Best, J. M. & Banatvala, J. E. (1978). Rubella serology by solid phase radioimmunoassay: its potential for screening purposes. Clinical and Experimental Immunology 31, 50.Google Scholar
Tómasson, H. O. & Ögmundsdóttir, H. M. (1975). Rubella in Iceland. Acta pathologica et microbiologica scandinavica Section B, 83, 275.Google ScholarPubMed
Welsh, K. I. & Batchelor, J. R. (1978). Handbook of Experimental Immunology (ed. Weir, D. M.). Oxford: Blackwell Scientific Publications.Google Scholar