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HLA antigens and responses to rubella vaccination

Published online by Cambridge University Press:  15 May 2009

Gillian C. Harcourt ,
Jennifer M. Best ,
J. E. Banatvala  and
Lesley A. Kennedy
Gillian C. Harcourt
Affiliation:
Department of Virology, St Thomas' Hospital and Medical School, London SE1 7EH
Jennifer M. Best
Affiliation:
Department of Virology, St Thomas' Hospital and Medical School, London SE1 7EH
J. E. Banatvala
Affiliation:
Department of Virology, St Thomas' Hospital and Medical School, London SE1 7EH
Lesley A. Kennedy
Affiliation:
Tissue Typing Laboratory, Guy's Hospital, London SE1 9RT
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Attempts were made to correlate virus excretion, joint symptoms and antibody response with human leukocyte antigens (HLA) in seronegative adult women given attenuated rubella vaccine. No association was shown between HLA antigens of the A and B loci and excretion of either high or low titres of RA27/3 vaccine among 26 volunteers. However, virus excretion was influenced by such factors as the time of day at which specimens were collected and the method of virus isolation. Our study therefore failed to confirm the hypothesis that certain persons are good ‘spreaders’ of rubella virus and that this capacity is associated with HLA-A1 and B8.

The study of joint symptoms following vaccination with Cendehill, HPV77. DE-5, RA27/3 or To-336 vaccines showed no association between such symptoms and HLA antigens. However, joint symptoms occurred within 7 days of the onset of menstruation in 33 of 47 (70%) vaccinees (P < 0.01) and it is therefore suggested that hormonal factors must play a role. No association between HLA antigens and haemagglutination inhibition (HAI) antibody titres, 8 weeks after vaccination with RA27/3, was found amongst 34 volunteers.

Type
Research Article
Information
Journal of Hygiene , Volume 83 , Issue 3 , December 1979 , pp. 405 - 412
Copyright
Copyright © Cambridge University Press 1979

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