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High prevalence of metallo-β-lactamase-mediated resistance challenging antimicrobial therapy against Pseudomonas aeruginosa in a Brazilian teaching hospital

Published online by Cambridge University Press:  07 July 2006

A. P. ZAVASCKI ,
L. Z. GOLDANI ,
A. L. S. GONÇALVES ,
A. F. MARTINS  and
A. L. BARTH
A. P. ZAVASCKI
Affiliation:
Infectious Diseases Service, Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil Medical Sciences Postgraduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
L. Z. GOLDANI
Affiliation:
Medical Sciences Postgraduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil Division of Infectious Diseases, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
A. L. S. GONÇALVES
Affiliation:
Microbiology Unit, Clinical Pathology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
A. F. MARTINS
Affiliation:
Microbiology Unit, Clinical Pathology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
A. L. BARTH
Affiliation:
Medical Sciences Postgraduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil Microbiology Unit, Clinical Pathology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
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Abstract

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The prevalence of metallo-β-lactamase (MBL) production among Pseudomonas aeruginosa nosocomial isolates from a Brazilian teaching hospital was determined. A total of 512 P. aeruginosa isolates were recovered from 245 patients during a 10-month period. Ninety-four (38·4%, 95% CI 32·2–44·8%) isolates were MBL producers. Most resistance to β-lactams was mediated by MBL. Forty-one (16·7%) were resistant to all drugs except polymyxin B and 33 (80·5%) of these were MBL producers. Clonal dissemination, documented by DNA macrorestriction, played a major role for the spread of MBL isolates. The blaSPM-1 gene was demonstrated by PCR in 14 randomly selected MBL isolates. The extremely high prevalence of MBL production found challenges the choice of therapeutics for P. aeruginosa, and measures to control horizontal dissemination of MBL producers are urgently required.

Type
Short Report
Information
Epidemiology & Infection , Volume 135 , Issue 2 , February 2007 , pp. 343 - 345
Copyright
2006 Cambridge University Press