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Gentamicin-resistant staphylococei: genetics of an outbreak in a dermatology department

Published online by Cambridge University Press:  19 October 2009

Jay Naidoo ,
W. C. Noble ,
A. Weissmann  and
K. G. H. Dyke
Jay Naidoo
Affiliation:
Institute of Dermatology, University of London
W. C. Noble
Affiliation:
Institute of Dermatology, University of London
A. Weissmann
Affiliation:
Department of Dermatology, University of Munich
K. G. H. Dyke
Affiliation:
Department of Biochemistry, University of Oxford
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Summary

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The genetics of gentamicin resistance in Staphylococcus aureus strains isolated during an outbreak of infection in a dermatology department have been studied. The predominant strain of S. aureus did not appear to possess a plasmid mediating gentamicin resistance though one isolate yielded a plasmid coding for penicillin and gentamicin. Three distinct plasmids were isolated from other phage types of S. aureus which appeared towards the end of the epidemic. There appeared to be a stepwise loss of gentamicin resistance in the predominant strain.

Type
Research Article
Information
Journal of Hygiene , Volume 91 , Issue 1 , August 1983 , pp. 7 - 16
Copyright
Copyright © Cambridge University Press 1983

References

REFERENCES

Bint, A. J., George, R. H., Healing, D. E., Wisk, R. & Davies, M. (1977). An outbreak of infection caused by a gentamicin-resistant Staphylococcus aureus. Journal of Clinical Pathology 30, 165–167.CrossRefGoogle ScholarPubMed
Chattopadhyay, B. & Teu, J. C. (1981). Gentamicin-resistant Staphylococcus aureus after topical therapy in general practice. Journal of Hospital Infection 2, 278–279.Google Scholar
Dyke, K. G. H., Naidoo, J. & Noble, W. C. (1983). Mapping of a plasmid of Staphylococcus aureus that confers resistance to gentamicin and penicillin. Submitted for publication.Google Scholar
Faden, H., Neter, W., McLaughlin, S. & Giacoia, G. (1979). Gentamicin-resistant Staphylococcus auretts. Emergence in an intensive care nursery. Journal of the American Medical Association 241, 143–145.Google Scholar
Graham, D. R., Correa-Villasenor, A., Anderson, R. L., Vollman, J. H. & Baine, W. B. (1980). Epidemic neonatal gentamicin-methicillin-resistant Staphylococcus aureus infection associated with non-specific topical use of gentamicin. Journal of Pediatrics 97, 972–978.CrossRefGoogle Scholar
Greenhood, G. P., Hill, D. L., Dixon, R. E., Carter, M. J. & Kanto, W. P. (1979). Changing phage-type patterns of epidemic gentamicin-resistant Staphylococcus aureus. Evidence for transmission of gentamicin-resistance. Lancet i, 289–291.CrossRefGoogle Scholar
Jaffe, H. W., Sweeney, H. M., Nathan, C., Weinstein, R. A., Kabins, S. A. & Cohen, S. (1980). Identity and interspecific transfer of gentamicin resistance plasmids in Staphylococcus aureus and Staphylococcus epidermidis. Journal of Infectious Diseases 141, 738–747.Google Scholar
Lacey, R. W. (1975). Antibiotic resistance plasmids of Staphylococcus aureus and their clinical importance. Bacteriological Reviews 39, 1–32.CrossRefGoogle ScholarPubMed
Naidoo, J. & Noble, W. C. (1978). Transfer of gentamicin resistance between strains of Staphylococcus aureus. Journal of General Microbiology 107, 391–393.CrossRefGoogle ScholarPubMed
Naidoo, J. & Noble, W. C. (1981). Transfer of gentamicin resistance between coagulase-negative and coagulase-positive staphylococci on skin. Journal of Hygiene (Cambridge) 86, 183–187.CrossRefGoogle ScholarPubMed
Novick, R. P., Murphy, E., Gryczan, T. J., Baron, E. & Edelman, I. (1979). Penicillinase plasmids of Staphylococcus aureus restriction-deletion maps. Plasmid 2, 109–129.CrossRefGoogle ScholarPubMed
Price, E. H., Brain, A. & Dickson, J. A. S. (1980). An outbreak of infection with a gentamicin and methicillin-resistant Staphylococcus aureus in a neonatal unit. Journal of Hospital Infection 1, 221–228.CrossRefGoogle Scholar
Schaefler, S., Jones, D., Perry, W., Ruvinskaya, L., Baradet, T., Mayr, E. & Wilson, M. E. (1981). Emergence of gentamicin and methicillin-resistant Staphylococcus aureus strains in New York City Hospitals. Journal of Clinical Microbiology 13, 754–759.Google Scholar
Shanson, D. C., Kensit, J. G. & Duke, R. (1976). Outbreak of hospital infection with a strain of Staphylococcus aureus resistant to gentamicin and methicillin. Lancet ii, 1347–1348.Google Scholar
Speller, D. C. E., Stephens, M., Raghunath, D., Viant, A. C., Reeves, D. S., Broughall, J. M., Wilkinsons, P. J. & Holt, H. A. (1976). Epidemic infection by a gentamicin-resistant S. aureus in three hospitals. Lancet i, 464–466.CrossRefGoogle Scholar
Wyatt, T. D., Ferguson, W. P., Wilson, T. S. & McCormick, E. (1977). Gentamicin resistant Staphylococcus aureus associated with the use of topical gentamicin. Journal of Antimicrobial Chemotherapy 3, 213–217.Google Scholar