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Genetic relationships among Escherichia coli isolates causing urinary tract infections in humans and animals

Published online by Cambridge University Press:  15 May 2009

Thomas S. Whittam ,
M. L. Wolfe  and
R. A. Wilson
Thomas S. Whittam
Affiliation:
Departments of Biology, Pennsylvania State University, University Park, Pennsylvania 16082, USA
M. L. Wolfe
Affiliation:
Departments of Biology, Pennsylvania State University, University Park, Pennsylvania 16082, USA
R. A. Wilson
Affiliation:
Departments of Veterinary Sciences, Pennsylvania State University, University Park, Pennsylvania 16082, USA
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Genetic variation in isolates of Escherichia coli obtained mostly from urinary tract infections in humans and domesticated animals (dogs and cats) was assessed for 16 enzymes using multilocus enzyme electrophoresis to characterize chromosomal genotypes. A total of 148 isolates comprised 63 distinct electrophoretic types (ETs) and about half of the isolates belonged to one of 9 common ETs. A bootstrap analysis of genetic distance between ETs revealed three significant groups of strains. Variation in allele frequencies among groups accounted for 40% of the total genetic diversity. The majority of the common ETs fell into a major cluster of closely related strains. The recovery of multiple isolates of the same electrophoretic types and serotypes from unassociated hosts suggests that these bacteria represent uropathogenic clones that are widely disseminated in humans and animals

Type
Research Article
Information
Epidemiology & Infection , Volume 102 , Issue 1 , February 1989 , pp. 37 - 46
Copyright
Copyright © Cambridge University Press 1989

References

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