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Genetic marker studies of poliovirus: I. Natural variation

Published online by Cambridge University Press:  15 May 2009

Yvonne E. Cossart
Yvonne E. Cossart
Affiliation:
Virus Reference Laboratory, Central Public Health Laboratory, Colindale Avenue, London, N. W. 9
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The properties of naturally occurring poliovirus strains of each serotype have been studied using three marker tests: the R.C.T.40 test, intratypic serodifferentiation and, for type 1 strains only, inhibition by dextran sulphate.

The results show that while most strains resemble the prototype strain of the same serotype, considerable natural variation exists, especially in the ability to grow at temperatures between 39° and 40° C.

No correlation has been found between the results of the tests on individual strains and it is concluded that no single test is sufficient to characterize a strain.

Type
Research Article
Information
Journal of Hygiene , Volume 65 , Issue 1 , March 1967 , pp. 67 - 76
Copyright
Copyright © Cambridge University Press 1967

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