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Further observations on enhancement of the infectivity of Fusobacterium necrophorum by other bacteria

Published online by Cambridge University Press:  15 May 2009

G. R. Smith ,
S. A. Barton  and
L. M. Wallace
G. R. Smith
Affiliation:
Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY
S. A. Barton
Affiliation:
Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY
L. M. Wallace
Affiliation:
Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY
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Summary

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It had already been shown with a single virulent strain (A42) of Fusobacterium necrophorum that suspension of the fusobacteria in sub-lethal doses of broth cultures of other bacteria reduced the minimum infective dose (> 106 organisms) for mice by subcutaneous inoculation, sometimes to < 10 organisms. The present study extended the known range of bacteria with strong infectivity-enhancing properties to include Bacillus cereus, Klebsiella oxytoca and Staphylococcus aureus; and of those with weaker effect to include Bacillus subtilis, ‘Bacteroides melaninogenicus’, Clostridium sporogenes, Pasteurella haemolytica, and Proteus mirabilis.

The study also showed that five further virulent strains of F. necrophorum closely resembled A42 in respect of striking susceptibility to infectivity enhancement by Escherichia coli, Actinomyces (Corynebacterium) pyogenes and S. aureus. One further strain (A6) of F. necrophorum resembled A42 in respect of strong infectivity enhancement by A. pyogenes, S. aureus, B. cereus and K. oxytoca but differed from it and the other five strains in being only slightly affected by E. coli.

This work was a necessary prelude to the development of a method, based on infectivity enhancement, for the detection and isolation of F. necrophorum present in small numbers in heavily contaminated material such as faeces.

Type
Special Article
Information
Epidemiology & Infection , Volume 106 , Issue 2 , April 1991 , pp. 305 - 310
Copyright
Copyright © Cambridge University Press 1991

References

REFERENCES

1.Smith, GR, Till, D, Wallace, LM, Noakes, DE. Enhancement of the infectivity of Fusobacterium necrophorum by other bacteria. Epidemiol Infect 1989; 102: 447–58.Google Scholar
2.Smith, GR, Barton, SA, Wallace, LM. A sensitive method for isolating Fusobacterium necrophorum from faeces. Epidemiol Infect 1991; 106: 311–317.Google Scholar
3.Smith, GR, Oliphant, JC, Parsons, R. The pathogenic properties of Fusobacterium and Bacteroides species from wallabies and other sources. J Hyg 1984; 92: 165–75.CrossRefGoogle ScholarPubMed
4.Smith, GR, Turner, A, Murray, LG, Oliphant, JC. The weak immunogenicity of Fusobacterium necrophorum. J Hyg 1985; 95: 59–68.CrossRefGoogle ScholarPubMed
5.Smith, GR, Turner, A. The adverse effect of dilution on the infectivity of Fusobacterium necrophorum culture. J Hyg 1986; 96: 199–203.CrossRefGoogle ScholarPubMed
6.Smith, GR, Turner, A, Cinderey, R. Susceptibility of wallabies to Fusobacterium necrophorum. Vet Rec 1986; 118: 691–3.CrossRefGoogle ScholarPubMed
7.Smith, GR, Wallace, LM, Till, D. Necrobacillosis and immunity in mice. Epidemiol Infect 1989; 103: 211–5.CrossRefGoogle ScholarPubMed
8.Smith, GR, Wallace, LM, Noakes, DE. Experimental observations on the pathogenesis of necrobacillosis. Epidemiol Infect 1990; 104: 73–8.Google Scholar
9.Deacon, AG, Duerden, BI, Holbrook, WP. Gas-liquid chromatographic analysis of metabolic products in the identification of Bacteroidaceae of clinical interest. J Med Microbiol 1978; 11: 81–99.Google Scholar
10.Berg, JN, Loan, RW. Fusobacterium necrophorum and Bacteroides melaninogenicus as etiologic agents of foot rot in cattle. Am J Vet Res 1975; 36: 1115–22.Google ScholarPubMed
11.Sterne, M, Batty, I. Pathogenic clostridia. London and Boston: Butterworth, 1975.Google Scholar
12.Beerens, H, Fievez, L, Wattre, P. Observations concernant 7 souches appartenant aux espèces Sphaerophorus necrophorus, Sphaerophorus funduliformis, Sphaerophorus pseudonecrophorus. Annls Inst Pasteur Lille 1971; 121: 37–41.Google Scholar
13.Hofstad, T. Fusobacterium necrophorum – pathogenic organism? J Med Microbiol 1985; 20: vii.Google Scholar