Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-05T21:44:07.775Z Has data issue: false hasContentIssue false
  • English
  • Français

Field trials of an inactivated oil-adjuvant vaccine against louping-ill (Arbovirus group B)

Published online by Cambridge University Press:  15 May 2009

J. G. Brotherston ,
C. C. Bannatyne ,
A. O. Mathieson  and
T. B. Nicolson
J. G. Brotherston
Affiliation:
Moredun Institute, Edinburgh
C. C. Bannatyne
Affiliation:
Scottish Veterinary Investigation Service
A. O. Mathieson
Affiliation:
Scottish Veterinary Investigation Service
T. B. Nicolson
Affiliation:
Scottish Veterinary Investigation Service
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A single dose of inactivated louping-ill oil-adjuvant vaccine elicited a serologically detectable immune response in sheep lasting for at least 1 year. These sheep when exposed to a natural focus of louping-ill virus were completely protected from clinical disease and 1 year after vaccination were able to pass on a substantial maternal immunity to their lambs.

Twenty-nine per cent of unvaccinated sheep, exposed at the same time, died from clinical louping-ill; half of the survivors showed positive sero-conversion and became immune, while the other half remained susceptible. The incidence of fatal encephalomyelitis in sheep which were known to have circulated virus exceeded 50% in 2 out of 3 trials conducted simultaneously in different locations in Scotland in 1969.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 3 , September 1971 , pp. 479 - 489
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Brambell, F. W. R. (1958). The passive immunity of the young mammal. Biological Reviews 33, 488.CrossRefGoogle Scholar
Brotherston, J. G. & Boyce, J. B. (1969). A new vaccine against louping-ill. Veterinary Record 84, 514.CrossRefGoogle ScholarPubMed
Brotherston, J. G. & Boyce, J. B. (1970). Development of a non-infective protective antigen against louping-ill (Arbovirus Group B). Journal of Comparative Pathology 80, 377.Google Scholar
Doherty, P. C. (1969). Louping-ill encephalitis in C 57 black mice. Journal of Comparative Pathology 79, 571.CrossRefGoogle Scholar
Doherty, P. C. & Reid, H. W. (1971). Louping-ill encephalomyelitis in the sheep. II. Distribution of virus and lesions in nervous tissue. Journal of Comparative Pathology (in the Press).Google Scholar
Foggie, A. (1951). Studies on the infectious agent of tick-borne fever in sheep. Journal of Pathology and Bacteriology 63, 1.CrossRefGoogle ScholarPubMed
Gordon, W. S., Brownlee, A., Wilson, D. R. & Macleod, J. (1962). The epizootiology of louping-ill and tick-borne fever with observations on the control of these diseases. Symposia of the Zoological Society of London, no. 6, pp. 1–27.Google Scholar
Macleod, J. & Gordon, W. S. (1932). Studies in louping-ill (an encephalomyelitis of sheep). II. Transmission by the sheep ticks Ixodes ricinus L. Journal of Comparative Pathology 45, 240.Google Scholar
Mayer, V., Blašovič, D., Ernek, E. & Libíková, J. (1969). The serological response and long-lasting resistance against infection with louping-ill virus in sheep immunized with a highly attenuated tick-borne encephalitis virus. Journal of Hygiene 67, 731.Google Scholar
O'Reilly, K. J., Smith, C. E. G., McMahon, D. A., Bowen, E. T. W. & White, G. (1968). A comparison of measuring the persistence of neutralizing and haemagglutinin-inhibiting antibodies to louping-ill virus in experimentally infected sheep. Journal of Hygiene 66, 217.CrossRefGoogle ScholarPubMed
Reid, H. W. & Doherty, P. C. (1971). Louping-ill encephalomyelitis in the sheep. I. The relationship of viraemia and the antibody response to susceptibility. Journal of Comparative Pathology 81, 291.Google Scholar
Smith, C. E. G. (1969). Arbovirus vaccines. British Medical Bulletin 25, 142.CrossRefGoogle ScholarPubMed
Smith, C. E. G., McMahon, D. A., O'Reilly, K. J., Wilson, A. L. & Robertson, J. M. (1964). The epidemiology of louping-ill in Ayrshire: the first year of studies in sheep. Journal of Hygiene 62, 53.CrossRefGoogle ScholarPubMed
Williams, H. & Thorburn, H. (1961). The serological response of sheep to louping-ill virus. Journal of Hygiene 59, 437.Google ScholarPubMed