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Exposure to enteroviruses and hepatitis A virus among divers in environmental waters in France, first biological and serological survey of a controlled cohort

Published online by Cambridge University Press:  19 October 2009

D. Garin ,
F. Fuchs ,
J. M. Crance ,
Y. Rouby ,
J. C. Chapalain ,
D. Lamarque ,
A. M. Gounot  and
M. Aymard
D. Garin
Affiliation:
Biologie Médicale (Dr Bartoli) Hôpital d'Instruction des Armées Desgenettes, 108, Bd Pinel, 69275 Lyon Cedex 3France
F. Fuchs*
Affiliation:
Agence du Médicament, Unité de Virologie, 8, Avenue Rockefeller, 69373 Lyon Cedex 08France
J. M. Crance
Affiliation:
Unité de Biologie Moléculaire (Dr Deloince) Centre de Recherche du Service de Santé des Armées, 24 Av. des Maquis du Grésivaudan BP 87 38702 La Tronche CedexFrance
Y. Rouby
Affiliation:
Biologie Médicale (Dr Bartoli) Hôpital d'Instruction des Armées Desgenettes, 108, Bd Pinel, 69275 Lyon Cedex 3France
J. C. Chapalain
Affiliation:
Biologie Médicale (Dr Bartoli) Hôpital d'Instruction des Armées Desgenettes, 108, Bd Pinel, 69275 Lyon Cedex 3France
D. Lamarque
Affiliation:
Médecine des collectivités, Hôpital d'Instruction des Armées Robert Piqué, 33998 Bordeaux ArméesFrance
A. M. Gounot
Affiliation:
Université Claude Bernard, Bât. 405, 43 Bd 11 Novembre 1918, 69622 Villeurbanne CedexFrance
M. Aymard
Affiliation:
Agence du Médicament, Unité de Virologie, 8, Avenue Rockefeller, 69373 Lyon Cedex 08France
*
*Reprints or correspondence: Florence Fuchs, Agence du Médicament. Direction des contrôles, 8, Avenue Rockefeller, 69373 Lyon Cedex 08 France.
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Summary

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An epidemiological study of hepatitis A and enteroviruses was conducted in a military diving training school, by evaluating the viral contamination of water using an ultrafiltration concentration technique, and assessing seroconversion and the presence of virus in stool specimens obtained from 109 divers and 48 controls. Three of 29 water specimens were positive for enterovirus by cell culture and 9 by molecular hybridization. There was little or no risk of virus infection during the training course (49 h exposure) because there was no significant difference between divers and controls for both viral isolation and seroconversion. However, a higher percentage of coxsackievirus B4 and B5 seropositive divers suggests that these were more exposed during previous water training. No hepatitis A virus (HAV) detection and no seroconversion to HAV was observed. The rate of HAV seropositive subjects was 17% in this 24·5-year-old population

Type
Research Article
Information
Epidemiology & Infection , Volume 113 , Issue 3 , December 1994 , pp. 541 - 549
Copyright
Copyright © Cambridge University Press 1994

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