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Experimental study of a further attenuated live measles vaccine of the Sugiyama strain in Iran

Published online by Cambridge University Press:  15 May 2009

H. Mirchamsy ,
A. Shafyi ,
M. R. Rafyi ,
S. Bahrami ,
P. Nazari  and
S. Fatemie
H. Mirchamsy
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
A. Shafyi
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
M. R. Rafyi
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
S. Bahrami
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
P. Nazari
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
S. Fatemie
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
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Summary

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After encouraging results of the mass vaccination programme in Iran, in which 5 million children in rural areas were vaccinated with the Japanese Sugiyama strain at its 82nd passage in baby calf kidney, and a progressive decrease in the incidence of measles as well as a reduction of excessive infant mortality, a further attenuated vaccine, produced with the same strain, cloned in Japan, was compared in a field trial with the parent vaccine. The new strain caused fewer reactions than the original strain. Seroconversion with a geometric mean antibody titre of 6·1 was observed in 95% of susceptible children.

Type
Research Article
Information
Journal of Hygiene , Volume 72 , Issue 2 , April 1974 , pp. 273 - 279
Copyright
Copyright © Cambridge University Press 1974

References

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