Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-31T15:16:52.210Z Has data issue: false hasContentIssue false
  • English
  • Français

Experimental Rickets

Published online by Cambridge University Press:  15 May 2009

Peter M. Holst
Peter M. Holst
Affiliation:
(From the Hygienic Institute of the University of Oslo.)
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Rickets is produced in rats by feeding exclusively with cereals and yellow peas. Whereas feeding with polished rice results in typical rickets, feeding with rice-starch alone will only produce osteoporosis. This difference is not attributable to nitrogen starvation.

If oatmeal is extracted with hydrochloric acid and the extract is given in addition to the starch, the animals develop rickets. The rickets-producing factor of oatmeal must therefore be ascribed to some toxic substance. Evidence is given to show that this substance can pass through parchment-paper and that it can be precipitated with alcohol. Rickets produced by feeding with cereals can be prevented by the administration of calcium-salts, whereas phosphates have no such effect.

Type
Research Article
Information
Journal of Hygiene , Volume 26 , Issue 4 , October 1927 , pp. 437 - 440
Copyright
Copyright © Cambridge University Press 1927

References

REFERENCES

Holst, P. M. (1922). Om vitaminer og tran. Forhandl, i Norsk Med. Selskap. 9th.Google Scholar
Holst, P. M.(1924 a). Om mangel paa vitamin A og rakit. Norsk Magazin for Laegevidenskaben, p. 933.Google Scholar
Holst, P. M. (1924 b). Experimental Rickets. Forhandl. ved Ellevte Nordiske Kongres for Indre Medicin i Kristiania, 1923.Google Scholar
Mccollum, E. V., Simmonds, N., Parsons, H. T., Shipley, P. G. and Park, E. A. (1921 a). Studies on Experimental Rickets. I. The Production of Rachitis and Similar Diseases in the Rat by Deficient Diets. J. Biol. Chem. 45, 333.Google Scholar
Mccollum, E. V., Simmonds, N., Shipley, P. G. and Park, E. A. (1922). Studies on Experimental Rickets. XXII. Conditions which must be fulfilled in preparing animals for testing the antirachitic effect of individual foodstuffs. Bull. Johns Hopkins Hospital, 33, 296.Google Scholar
Mellanby, E. (1925). Experimental Rickets. Medical Research Council Special Report Series No. 93. London.Google Scholar
Mellanby, E. (1926). The Presence in Foodstuffs of Substances having Specific Harmful Effects under Certain Conditions. Proc. Physiol. Soc. March 20th, 1926, J. Physiol. 61.Google Scholar
Shipley, P. G., Park, E. A., Mccollum, E. V., Simmonds, N. and Parsons, H. T. (1921 b). Studies on Experimental Rickets. II. The Effect of Cod liver Oil administred to Rats with Experimental Rickets. J. Biol. Chem. 45, 343.Google Scholar
Weiske, (1895). Versuche über die Wirkung einer Beigabe von Calcium-, Strontium- resp. Magnesiumcarbonat zu einem kalkarmen aber phosphorsäurereichen Futter auf den thierschen Organismus, insbesondere auf die Zusammensetzung des Skelettes. Zeitsehr.f. Biol. 31, 421.Google Scholar