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Evaluation of live attenuated measles vaccines prepared in human diploid cells for reimmunization

Published online by Cambridge University Press:  15 May 2009

H. Mirchamsy ,
A. Shafyi ,
P. Nazari ,
M. P. Ashtiani  and
A. Sassani
H. Mirchamsy
Affiliation:
Razi State Serum Institue, P.O. Box 11365—1558, Tehran, Islamic Republic of Iran
A. Shafyi
Affiliation:
Razi State Serum Institue, P.O. Box 11365—1558, Tehran, Islamic Republic of Iran
P. Nazari
Affiliation:
Razi State Serum Institue, P.O. Box 11365—1558, Tehran, Islamic Republic of Iran
M. P. Ashtiani
Affiliation:
Razi State Serum Institue, P.O. Box 11365—1558, Tehran, Islamic Republic of Iran
A. Sassani
Affiliation:
Razi State Serum Institue, P.O. Box 11365—1558, Tehran, Islamic Republic of Iran
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Summary

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Two live attenuated measles vaccines developed in baby calf kidney cells, a similar vaccine produced in chick embryo chorioallantoic cells and five vaccines prepared from human diploid cells (HDC) have been studied by subcutaneous injection in groups of susceptible and immune children in three field trials. The results indicated that the vaccine developed in chick embryo cells which caused mild clinical reactions, had induced a lower seroprotection rate in susceptible children and only a low rise in hemagglutination-inhibition (HI) antibody titre in previously immunized children. The serological responses induced by vaccines developed in HDC or in calf kidney cells were satisfactory in both susceptible and immune children. The superiority of HDC grown measles vaccine for revaccination is discussed.

Type
Research Article
Information
Epidemiology & Infection , Volume 101 , Issue 2 , October 1988 , pp. 437 - 443
Copyright
Copyright © Cambridge University Press 1988

References

Böttinger, M., Heller, L., Kamensky, P. & Svanberg, B., (1973). Conversion rates and side effects following vaccination with three different batches of the ‘Schwarz’ measles strain. Journal of Biological Standardization 1, 225–231.CrossRefGoogle Scholar
Centers for Disease Control (1977). Measles surveillance, Reports no. 10.Google Scholar
Centers for Disease Control (1986). Morbidity and Mortality Weekly Report 35, 533.Google Scholar
Cherry, J. D., Feigin, R. D., Lobes, L. A., Hinthorn, D. R., Shirley, R. H., Linds, R. D. & Choi, S. C. (1972). Urban measles in the vaccine era: A clinical, epidemiological and serologic study. Journal of Pediatrics 81, 217–230.CrossRefGoogle Scholar
Cherry, J. D., Feigin, R. D., Shackelford, P. G., Hinthorn, D. R. & Schmidt, R. R. (1973). A Clinical and serologic study of 103 children with measles vaccine failure. Journal of Pediatrics 82, 802–808.CrossRefGoogle ScholarPubMed
Goffe, A. P. & Laurence, G. D. (1961). Vaccination against measles. I. Preparation and testing of vaccines consisting of living attenuated virus. British Medical Journal 2, 1244.CrossRefGoogle ScholarPubMed
Hsin-Chun, , Hsü, , T'eh–Chang, , Tseng, Kuo-hua, chang, Shou-Teh, Wu, wen-hian, Chu–Chi–Ming, , Ku, Yu-Fen, Yang, Chü–Yeh & Ho, Lan (1975). Clinical and immunological observations on two lines of attenuated measles vaccine virus upon passage in chick embryo cell culture. Chinese Medical Journal 1, 283–286.Google Scholar
Leading Article. (1969). A measles vaccine withdrawn. British Medical Journal 1, 794–795.CrossRefGoogle Scholar
Linnemann, C. C., Rotte, T. C., Schiff, G. M. & Youtesey, J. L. (1972). A seroepidemiologic study of a measles epidemic in a highly immunized population. American Journal of Epidemiology 95, 238.Google Scholar
Makino, S., Sasaki, K. & Nakamura, N. (1973a). Field trial with a further attenuated live measles vaccine. Japanese Journal of Microbiology 17, 75–79.Google Scholar
Makino, S., Sasaki, K. & Nakamura, N. (1973b). Evaluation of the live AIK measles virus vaccine. Kitasato Archives of Experimental Medicine 46, 83–92.Google Scholar
Matumoto, M., Mutai, M., Saburi, Y., Fujii, R., Minamitani, M. & Nakamura, K. (1962). Live measles vaccine: clinical trial of vaccine prepared from a variant of the Sugiyama strain adapted to bovine kidney cells. Japanese Journal of Experimental Medicine 32, 433–448.Google ScholarPubMed
Mirchamsy, H., Nazari, F., Stellman, C. & Esterabady, H. (1968). The use of dried blood absorbed on filter paper for evaluation of diphtheria and tetanus antitoxins in mass surveys. Bulletin of the World Health Organization 38, 665–671.Google ScholarPubMed
Mirchamsy, H., Shafyi, A., Bassali, Y., Bahrami, S., & Nazari, F. A. (1970). Comparative study of two live measles vaccines in Iran. Journal of Hygiene 68, 101–110.CrossRefGoogle ScholarPubMed
Mirchamsy, H., Shafyi, A., Rafyi, M. R., Bahrami, S., Nazari, P. & Fatemi, S. (1974). Experimental study of a further attenuated measles vaccine of the Sugiyama strain in Iran. Journal of Hygiene 72, 273–279.CrossRefGoogle ScholarPubMed
Mirchamsy, H., Shafyi, A., Bahrami, S., Kamali, M., Nazari, P., Razavi, J., Ahourai, P., Fatemi, S. & Amin Salehi, M. C. A. (1977). A comparative field trial of five measles vaccines produced, in human diploid cell MRC–5. Journal of Biological Standardization 5, 1–18.CrossRefGoogle ScholarPubMed
Okuno, Y., Sugai, T., Toyoshima, K., Takahashi, M., Yamamura, T., Hata, S., Niki, T., Nakamura, K., Ueda, S. & Kunita, N. (1960). Studies on the prophylaxis of measles with attenuated living virus. IV. Inoculation tests in children with chick embryo passage measles virus in 1960. Biken Journal 3, 293–300.Google Scholar
Sabin, A. B., Arechiga, A. F., Castro, Jorgefernandez, De, Albrecht, P., Sever, J. L. &Shekarchi, I. (1984). Successful immunization of infants with and without maternal antibody by aerosolized measles vaccine II. Vaccine comparisons and evidence for multiple antibody response. Journal of the American Medical Association 251, 2363–2371.CrossRefGoogle ScholarPubMed
Schwarz, A. J. F. (1962). Preliminary tests of highly attenuated measles vaccine. American Journal of Diseases of Children 103, 386–389.Google Scholar
Ueda, S., Hosai, H., Minekawa, Y. & Okuno, Y. (1966). Studies on the combined use of killed and live measles vaccine. III. Conditions for the ‘take’ of live vaccine. Biken Journal 9, 97–101.Google Scholar