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Escherichia coli in extra-intestinal infections

Published online by Cambridge University Press:  19 October 2009

Ida Ørskov  and
Frits Ørskov
Ida Ørskov
Affiliation:
International Escherichia and Klebsiella Centre (WHO), Statens Seruminstitut, Copenhagen, Denmark
Frits Ørskov
Affiliation:
International Escherichia and Klebsiella Centre (WHO), Statens Seruminstitut, Copenhagen, Denmark
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When Theodor Escherich (1885a, b) first described Escherichia coli he looked on it as a saprophytic organism. Soon several investigators found that colibacteria could be isolated from intestinal infections and from many infections outside the intestine, like urinary tract infections (UTI), cholecystitis, wound infections, meningitis, septicaemia, pulmonary infections, and many more. Uhlenhuth (1897) showed that coli strains from pathological processes were more pathogenic in animal experiments than strains isolated from the normal intestine. Smith (1927), who examined strains from white scours in calves, showed that spontaneous acapsular mutants could be obtained from certain colibacteria, and that such mutants were less virulent when injected intra-peritoneally into guinea-pigs.

Type
Research Article
Information
Journal of Hygiene , Volume 95 , Issue 3 , December 1985 , pp. 551 - 575
Copyright
Copyright © Cambridge University Press 1985

References

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